Search results for: á_ Methyl_ n_ butyrylshikonin
#29165897 
2017/11/22
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Lithospermum erythrorhizon Root and its Naphthoquinones Repress SREBP1c and Activate PGC1α Through AMPKα.
To examine specific molecular mechanisms involved in modulating hepatic lipogenesis and mitochondria biogenesis signals by Lithospermum erythrorhizon (gromwell) root extract.Rodney A Velliquette, Arun Rajgopal, John Rebhun, Kelly Glynn
2540 related Products with: Lithospermum erythrorhizon Root and its Naphthoquinones Repress SREBP1c and Activate PGC1α Through AMPKα.
2.5 mg200ug10 mg0.1 mg2.5 mg 5 G1,000 tests100ug1 mg50 ug 100ug
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#26947902 2016/03/03
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Bioassay-guided isolation of wound healing active compounds from Echium species growing in Turkey.
The roots and root barks of Echium sp. have been used to treat ulcers, burns and wounds in traditional Turkish medicine.Nuraniye Eruygur, Gülderen Yılmaz, Osman Kutsal, Gözde Yücel, Osman Üstün
2785 related Products with: Bioassay-guided isolation of wound healing active compounds from Echium species growing in Turkey.
50ul 100ul300 units50ul 100ul50 ug 100ul1 Product tipe: Instrumen50ul100ug 100ul
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#19233376 2009/02/05
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Identification of shikonin and its ester derivatives from the roots of Echium italicum L.
Nine shikonin pigments: shikonin (S), acetylshikonin (AS), propionylshikonin (PS), isobutyrylshikonin (IBS), tiglylshikonin (TS), 3,3-dimethylacrylshikonin (DAS), angelylshikonin (ANS), 2-methyl-n-butyrylshikonin (MBS) and isovalerylshikonin (IVS) were identified in the root epidermis of Echium italicum L. for the first time. A new thin-layer chromatographic (TLC) method for the separation of enantiomers alkannin and shikonin proved only shikonin after saponification of the root extract, and was afterwards esterified with the corresponding acyl chloride to acquire seven standard compounds (all except ANS). The developed isocratic high-peformance liquid chromatographic (HPLC) methods with VIS and mass spectrometry (MS) detection, allowed for the first time simultaneous separation of all nine compounds with similar structures including positional and geometric isomers in a short time. Structures of the main five compounds (AS, IBS, ANS, MBS, IVS) isolated from the extract by a new semi-preparative HPLC on C18 have additionally been confirmed by (1)H and (13)C nuclear magnetic resonance spectra, which were reported for AS and MBS for the first time.Alen Albreht, Irena Vovk, Breda Simonovska, Marija Srbinoska
2464 related Products with: Identification of shikonin and its ester derivatives from the roots of Echium italicum L.
5 G 5 G10 mg100 mg100 assays25 mg10 G250 mg50 mg200 units25 mg5 g
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#17723649 2006/06/20
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Simultaneous determination of naphthoquinone derivatives in Boraginaceous herbs by high-performance liquid chromatography.
A high-performance liquid chromatographic method using diode-array detection (HPLC-DAD) has been developed for the simultaneous quantification of eight naphthoquinone derivatives namely shikonin, acetylshikonin, deoxyshikonin, beta-acetoxyisovalerylshikonin, isobutylshikonin, beta,beta-dimethylacrylshikonin, 2-methyl-n-butyrylshikonin and isovalerylshikonin in nine species of the Boraginaceae family. These species, coming from different areas of China, are all used as interchangeable sourcing plants for the Chinese Materia Medica known as "Zicao", and are Arnebia euchroma (Royle) Johnston., A. guttata Bunge, Lithospermum erythrorhizon Sieb. et Zucc., Onosma paniculatum Bur. et Franch., O. exsertum Hemsl., O. confertum W.W. Smith, O. hookerii Clarke var. longiflorum Duthie, O. hookerii Clarke and O. waltonii Duthic. Quantification of the eight naphthoquinones in all the Zicao samples are reported and compared with each other. Furthermore, two positional isomers, 2-methyl-n-butyrylshikonin and isovalerylshikonin, were successfully separated and quantified for the first time in the present study. The results showed that, besides the three officially used species (namely, A. euchroma, A. guttata and L. erythrorhizon) that were listed in Chinese pharmacopoeia as interchangeable sourcing plants for Zicao, other six species of Onosma used by native peoples in Tibet and Yunnan Province also contain various types and considerable amounts of naphthoquinones and that O. waltonii contains the most. Therefore, these species of Onosma could be developed as new sources of naphthoquinones. The entire analytical procedure is reproducible and suitable for the quantification of naphthoquinones in all related Boraginaceous plants for quality assessment purposes.Yani Hu, Zhihong Jiang, Kelvin Sze-Yin Leung, Zhongzhen Zhao
2658 related Products with: Simultaneous determination of naphthoquinone derivatives in Boraginaceous herbs by high-performance liquid chromatography.
400Tests20 100 100 20 20 20 96T100
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#11395262 //
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Shikonin production by p-fluorophenylalanine resistant cells of Lithospermum erythrorhizon.
Studies were conducted with a BK-39 callus culture of Lithospermum erythrorhizon, which produced seven shikonin derivatives (acetylshikonin, propionylshikonin, isobutyrylshikonin, beta,beta-dimethylacrylshikonin, isovalerylshikonin, beta-hydroxyisovalerylshikonin and alpha-methyl-n-butyrylshikonin). A selection of cell aggregates of BK-39 culture on a medium containing p-fluorophenylalanine (PFP) yields a cell line possessing a higher resistance to the inhibitor than the initial culture. Selected BK-39F cultures produced almost the same profile of shikonin naphthoquinones as the initial culture. The shikonin derivative content of PFP-resistant culture was approximately two times higher than that of the control, reaching 12.6% of DW cell biomass.V P Bulgakov, M M Kozyrenko, S A Fedoreyev, N P Mischenko, V A Denisenko, L V Zvereva, T V Pokushalova, Y N Zhuravlev