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#38634474   // To Up

Antiviral activity of adenoviral vector expressing human interferon lambda-4 against influenza virus.

Interferon lambda (IFNλ), classified as a type III IFN, is a representative cytokine that plays an important role in innate immunity along with type I IFN. IFNλ can elicit antiviral states by inducing peculiar sets of IFN-stimulated genes (ISGs). In this study, an adenoviral vector expression system with a tetracycline operator system was used to express human IFNλ4 in cells and mice. The formation of recombinant adenovirus (rAd-huIFNλ4) was confirmed using immunohistochemistry assays and transmission electron microscopy. Its purity was verified by quantifying host cell DNA and host cell proteins, as well as by confirming the absence of the replication-competent adenovirus. The transduction of rAd-huIFNλ4 induced ISGs and inhibited four subtypes of the influenza virus in both mouse-derived (LA-4) and human-derived cells (A549). The antiviral state was confirmed in BALB/c mice following intranasal inoculation with 10 PFU of rAd-huIFNλ4, which led to the inhibition of four subtypes of the influenza virus in mouse lungs, with reduced inflammatory lesions. These results imply that human IFNλ4 could induce antiviral status by modulating ISG expression in mice.
Dong-Hwi Kim, Jae-Hyeong Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Dong-Hun Lee, In-Soo Choi

1404 related Products with: Antiviral activity of adenoviral vector expressing human interferon lambda-4 against influenza virus.

1.00 ml96T 100ul1 kit(96 Wells)1.00 flask25 1 mg10 1 mg2 100 1.00 flask

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#38634239   2024/04/17 To Up

Bioinformatics-based analysis of the relationship between plasminogen regulatory genes and photoaging.

Ultraviolet radiation causes skin photoaging by producing a variety of enzymes, which impact both skin health and hinder beauty. Currently, the early diagnosis and treatment of photoaging remain a challenge. Bioinformatics analysis has strong advantages in exploring core genes and the biological pathways of photoaging.
Tengyu Weng, Xiaoning Zhang, Juan He, Yi Yang, Chengxin Li

2639 related Products with: Bioinformatics-based analysis of the relationship between plasminogen regulatory genes and photoaging.

1000 tests1 kit(96 Wells)100 1 ml1 module 15 ml 100ul100ug0.1mg1 module

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#38633245   2024/04/03 To Up

Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus.

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Diana Diaz-Cánova, Ugo Moens, Annika Brinkmann, Andreas Nitsche, Malachy Ifeanyi Okeke

2814 related Products with: Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus.

1100 µg100 1 mg100ul2100 1 mg25100 10 1 ml

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#38633177   2024/01/31 To Up

Expression of recombinant Florida clade 2 hemagglutinin in baculovirus expression system: A step for subunit vaccine development against H3N8 equine influenza virus.

Equine influenza (EI) is a transmissible viral respiratory sickness of the family. Two viruses, H7N7 and H3N8 caused EI; however, H7N7 has not been detected for decades. H3N8 has circulated and bifurcated into Eurasian and American lineages. The latter subsequently diversified into Kentucky, South America, and Florida sub-lineages. Florida clade 1 (FC1) and Florida clade 2 (FC2) strains are the only circulating EI viruses (EIVs) in the meantime. Immunization is considered the major means for the prevention and control of EI infection. Using disparate technologies and platforms, several vaccines have been developed and commercialized. According to the recommendations of the World Organization for Animal Health (WOAH), all commercial vaccines shall comprise representatives of both FC1 and FC2 strains. Unfortunately, most of the commercially available vaccines were not updated to incorporate a representative of FC2 strains.
Ahmed S Atwa, Lamis Gomaa, Wael Elmenofy, Haitham M Amer, Basem M Ahmed

2575 related Products with: Expression of recombinant Florida clade 2 hemagglutinin in baculovirus expression system: A step for subunit vaccine development against H3N8 equine influenza virus.

1100 10 100 100 100 2 10 10 2 2 300 units

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#38632693   2024/04/17 To Up

Strong resistance to β-cyfluthrin in a strain of the beetle Alphitobius diaperinus: a de novo transcriptome analysis.

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Gwenola Gouesbet, David Renault, Stéphane A P Derocles, Hervé Colinet

2551 related Products with: Strong resistance to β-cyfluthrin in a strain of the beetle Alphitobius diaperinus: a de novo transcriptome analysis.

1 mg100 ul1 module

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#38632598   2024/04/17 To Up

Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARγ/miR-7b-5p/Sp1 signaling pathway.

Toxoplasma gondii, an obligate intracellular parasitic protozoa, infects approximately 30% of the global population. Contracting T. gondii at the primary infection of the mother can result in neonatal microcephaly, chorioretinitis, hydrocephalus, or mortality. Our previous study indicated that pregnant mice infected with T. gondii displayed a decrease in both the number and the suppressive ability of regulatory T cells, accompanied by the reduced Forkhead box P3 (Foxp3). Numerous studies have proved that microRNAs (miRNAs) are implicated in T. gondii infection, but there is meager evidence on the relationship between alterations of miRNAs and downregulation of Foxp3 induced by T. gondii.
Yue Zhong, Cheng Qin, Qing Wang, Maoyuan Ding, Chong Qiu, Yunzhao Xu, Jinling Chen

1627 related Products with: Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARγ/miR-7b-5p/Sp1 signaling pathway.

1 mg2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box

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#38632224   2024/04/17 To Up

Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems.

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Giuliano De Carluccio, Virginia Fusco, Diego di Bernardo

2530 related Products with: Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems.

300 units96T250ul496T

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#38631714   2024/04/16 To Up

Efficacy of LCMV-based cancer immunotherapies is unleashed by intratumoral injections of polyI:C.

Lymphocytic choriomeningitis virus (LCMV) belongs to the Arenavirus family known for inducing strong cytotoxic T-cell responses in both mice and humans. LCMV has been engineered for the development of cancer immunotherapies, currently undergoing evaluation in phase I/II clinical trials. Initial findings have demonstrated safety and an exceptional ability to activate and expand tumor-specific T lymphocytes. Combination strategies to maximize the antitumor effectiveness of LCMV-based immunotherapies are being explored.
Celia Gomar, Claudia Augusta Di Trani, Angela Bella, Leire Arrizabalaga, Jose Gonzalez-Gomariz, Myriam Fernandez-Sendin, Maite Alvarez, Joan Salvador Russo-Cabrera, Nuria Ardaiz, Fernando Aranda, Timo Schippers, Marisol Quintero, Ignacio Melero, Klaus K Orlinger, Henning Lauterbach, Pedro Berraondo

1926 related Products with: Efficacy of LCMV-based cancer immunotherapies is unleashed by intratumoral injections of polyI:C.

100ul 5 G100ug Lyophilized100ug Lyophilized100ug Lyophilized0.1ml100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#38631709   2024/04/17 To Up

Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment.

Engineered arenavirus vectors have recently been developed to leverage the body's immune system in the fight against chronic viral infections and cancer. Vectors based on Pichinde virus (artPICV) and lymphocytic choriomeningitis virus (artLCMV) encoding a non-oncogenic fusion protein of human papillomavirus (HPV)16 E6 and E7 are currently being tested in patients with HPV16+ cancer, showing a favorable safety and tolerability profile and unprecedented expansion of tumor-specific CD8 T cells. Although the strong antigen-specific immune response elicited by artLCMV vectors has been demonstrated in several preclinical models, PICV-based vectors are much less characterized.
Josipa Raguz, Catarina Pinto, Theresa Pölzlbauer, Mohamed Habbeddine, Sandra Rosskopf, Judith Strauß, Valentin Just, Sarah Schmidt, Katell Bidet Huang, Felix Stemeseder, Timo Schippers, Ethan Stewart, Jakub Jez, Pedro Berraondo, Klaus K Orlinger, Henning Lauterbach

1080 related Products with: Preclinical evaluation of two phylogenetically distant arenavirus vectors for the development of novel immunotherapeutic combination strategies for cancer treatment.

1 G 5 G10 mg 1 G100 TESTS500 ml2x96 well plate 500 ml 100 mg0.2 mg1.0 mg

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#38631181   2024/04/15 To Up

Generation of a human induced pluripotent stem cell line (SHUPLi002-A) from PBMCs of a healthy female donor.

H
Beixu Li, Xing Ye, Junyi Lin, Kaijun Ma, Meng He, Youxin Fang

1475 related Products with: Generation of a human induced pluripotent stem cell line (SHUPLi002-A) from PBMCs of a healthy female donor.

1 mg500ug200 100 1 kit(96 Wells)1.00 flask100 μg10 Plates200 1 kit(96 Wells)

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