Search results for: miRNASelect™ pEP_hsa_mir_135a_1 Expression Vector
#38691208 
2024/05/01
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pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells.
BFatemeh Mahmoudi-Filabadi, Abbas Doosti
1542 related Products with: pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells.
1
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#38689599 2024/04/30
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Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno-associated virus vectors expressing human P301L tau.
Alzheimer's disease (AD) is a progressive neurodegenerative disease in which extracellular aggregates of the amyloid beta (Aβ) peptide precede widespread intracellular inclusions of the microtubule-associated protein tau. The autosomal dominant form of AD requires mutations that increase production or aggregation of the Aβ peptide. This has led to the hypothesis that amyloid deposition initiates downstream responses that lead to the hyperphosphorylation and aggregation of tau.Dylan J Finneran, Taylor Desjarlais, Alayna Henry, Brianna M Jackman, Marcia N Gordon, David Morgan
2998 related Products with: Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno-associated virus vectors expressing human P301L tau.
100.00 ug1 mg100 μg50ul100.00 ug0.5 mg1mg1 mg100uL0.1 mg100 μg200
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#38689536 2024/04/30
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Synergistic effects of miR-143 with miR-99a inhibited cell proliferation and induced apoptosis in breast cancer.
BZahra Doosti, Syed Omar Ebrahimi, Mahshid Samie Ghahfarokhi, Somayeh Reiisi
1954 related Products with: Synergistic effects of miR-143 with miR-99a inhibited cell proliferation and induced apoptosis in breast cancer.
96 assays2 Pieces/Box
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#38689341 2024/04/30
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Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid.
The cancer microbiota was considered the main risk factor for cancer progression. We had proved that Fusobacterium periodonticum (F.p) was higher abundance in Esophageal cancer(EC)tissues. Bioinformation analysis found that BCT was a key virulence protein of F.p. However, little is known about the role and mechanism of BCT in EC. This study aimed to recognize the key virulence protein of F.p and explore the mechanism of BCT in promoting EC.Xinxin Guo, Ping Wan, Weitao Shen, Mingjun Sun, Zhenyan Peng, Yinghao Liao, Yang Huang, Ran Liu
1856 related Products with: Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid.
100ul101mg596T 1 G1mg1 mL
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#38688426 2024/04/28
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SERCA2 protects against cisplatin-induced damage of auditory cells: Possible relation with alleviation of ER stress.
SERCA2, one of the P-type pumps encoded by gene ATP2A2, is the only calcium reflux channel of the endoplasmic reticulum (ER) and participates in maintaining calcium homeostasis. The present study was designed to explore SERCA2 expression pattern in auditory hair cells and the possible mechanism underlying the effects of SERCA2 on cisplatin-induced ototoxicity.Yue Xu, Hao Zhao, Fan Wang, Shuai Xu, Chen Wang, Yanan Li, Yajie Wang, Huiming Nong, Junhong Zhang, Zhixin Cao, Chengfang Chen, Jianfeng Li
1685 related Products with: SERCA2 protects against cisplatin-induced damage of auditory cells: Possible relation with alleviation of ER stress.
5 G2 ml96 assays100ug Lyophilized1.00 flask200ug2100ug 25 G1 mg 100ul
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#38688023 2024/05/01
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Construction of a Lentiviral Vector for Fgfr2 Overexpression and its Impact on the Biological Behavior of Cranial Suture Mesenchymal Stem Cells.
Suture mesenchymal stem cells (SuSCs), possessing self-renewal and multilineage differentiation abilities, play a crucial role in cranial bone growth. However, the impact of the disease-causing fibroblast growth factor receptor 2 (FGFR2) mutation on SuSCs in Crouzon syndrome has not been explored. This study aims to employ a lentivirus to overexpress Fgfr2 and investigate its role in the pathogenesis of Crouzon syndrome.Yingying Yue, Zong Chen, Xinhang Dong, Guodong Song, Xiaolei Jin
1377 related Products with: Construction of a Lentiviral Vector for Fgfr2 Overexpression and its Impact on the Biological Behavior of Cranial Suture Mesenchymal Stem Cells.
5 x 10A5 cells/vial24 wells10096T100μg25 g 1 kit(s) 10 mg0.1 mg100ul0.2 mg
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#38687912 2024/04/30
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Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis.
Allergic asthma (AA) is common in children. Excess copper is observed in AA patients. It is currently unclear whether copper imbalance can cause cuproptosis in pediatric AA. The datasets about pediatric AA (GSE40732 and GSE40888) were obtained from Gene Expression Omnibus (GEO) database. The expression of cuproptosis-related genes (CRGs) and immune cell infiltration in pediatric AA samples were analyzed. Single-cell RNA sequencing (scRNA-seq) data (GSE193816) were used to evaluate the expression patterns of CRGs in AA. The identification of differentially expressed genes within clusters was conducted using weighted gene co-expression network analysis. Subsequently, disease progression and cuproptosis-related models were screened using random forest (RF), support vector machine (SVM), extreme gradient boosting (XGBoost), and general linear model (GLM) algorithms. Four CRGs were notably increased in pediatric AA samples. CD4 T cells, macrophages and mast cells exhibited a lower cuproptosis score in AA samples, indicating that these immune cells may be closely associated with cuproptosis in AA development. Co-expression network of CRGs in AA was constructed. AA samples were divided into two cuprotosis clusters. Following construction of four machine-learning models, SVM model exhibited the highest efficacy of prediction in the testing set (AUC = 0.952). SVM model containing five important variables can be used for prediction of AA. This work provided a machine learning model containing five important variables, which may have good diagnostic efficiency for pediatric AA.Jingping Liu, Yujia Sun, Chunxin Tian, Dong Qin, Lanying Gao
1079 related Products with: Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis.
100 ug1 mg100ug2 Pieces/Box100 µg 100ul2 Pieces/Box2 x 100 500 reactions 100ul2 Pieces/Box
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#38687720 2024/04/30
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Electric pulse exposure reduces AAV8 dosage required to transduce HepG2 cells.
WYizhou Yao, Robert W Holdcraft, Susan C Hagness, John H Booske
2712 related Products with: Electric pulse exposure reduces AAV8 dosage required to transduce HepG2 cells.
1.00 flask100 extractions100ul25 50 mg100 extractions1.00 flask 125 ml 50 1 mg5 x 200ul/Unit
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#38687324 //
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Molecular mechanisms behind the generation of pro-oncogenic HIV-1 matrix protein p17 variants.
HAlberto Zani, Serena Messali, Antonella Bugatti, Matteo Uggeri, Alessandro Rondina, Leonardo Sclavi, Francesca Caccuri, Arnaldo Caruso
2108 related Products with: Molecular mechanisms behind the generation of pro-oncogenic HIV-1 matrix protein p17 variants.
10001000 100ul100ul100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized10mg 100ul
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#38686580 2024/04/30
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Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm.
Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of the mechanisms underlying AAA development and progression. Activating transcription factor (ATF) 3 has been increasingly recognized as a key regulator of cardiovascular diseases. However, the role of ATF3 (activating transcription factor 3) in AAA development and progression remains elusive.Ying Wen, Yingying Liu, Qiang Li, Jinlin Tan, Xing Fu, Yiwen Liang, Yonghua Tuo, Luhao Liu, Xueqiong Zhou, Dongkai LiuFu, Xuejiao Fan, Chaofei Chen, Zheng Chen, Zhouping Wang, Shunyang Fan, Renjing Liu, Lei Pan, Yuan Zhang, Wai Ho Tang