Search results for: miRNASelect™ pEGP-mmu-mir-698 Expression Vector
#38652220 
2024/04/23
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CA1 Modulates the Osteogenic Differentiation of Dental Follicle Stem Cells by Activating the BMP Signaling Pathway In Vitro.
Carbonic anhydrase 1 (CA1) has been found to be involved in osteogenesis and osteoclast in various human diseases, but the molecular mechanisms are not completely understood. In this study, we aim to use siRNA and lentivirus to reduce or increase the expression of CA1 in Dental follicle stem cells (DFSCs), in order to further elucidate the role and mechanism of CA1 in osteogenesis, and provide better osteogenic growth factors and stem cell selection for the application of bone tissue engineering in alveolar bone fracture transplantation.Jin-Ze Zhao, Ying-Ying Ge, Ling-Fa Xue, Yao-Xiang Xu, Jin Yue, Cong Li, Wen-Lin Xiao
1743 related Products with: CA1 Modulates the Osteogenic Differentiation of Dental Follicle Stem Cells by Activating the BMP Signaling Pathway In Vitro.
10 ug2 Pieces/Box2 Pieces/Box14 inhibitors1.5 x 10^6 cellsInhibitors124 wells
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#38652190 2024/04/23
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An Efficient Vector-Based CRISPR/Cas9 System in Zebrafish Cell Line.
TXiaokang Ye, Jiali Lin, Qiuji Chen, Jiehuan Lv, Chunsheng Liu, Yuping Wang, Shuqi Wang, Xiaobo Wen, Fan Lin
1502 related Products with: An Efficient Vector-Based CRISPR/Cas9 System in Zebrafish Cell Line.
1 mL1 mL100 μg96 tests100ug Lyophilized100 μg100ug Lyophilized100 μg100ug Lyophilized100 μg
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#38652170 2024/04/23
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Single-cell RNA sequencing reveals that an imbalance in monocyte subsets rather than changes in gene expression patterns is a feature of postmenopausal osteoporosis.
TLin Tao, Wen Jiang, Hao Li, Xiaochuan Wang, Zixuan Tian, Keda Yang, Yue Zhu
2416 related Products with: Single-cell RNA sequencing reveals that an imbalance in monocyte subsets rather than changes in gene expression patterns is a feature of postmenopausal osteoporosis.
100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized
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#38651368 2024/04/03
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TNFR1 Absence Is Not Crucial for Different Types of Cell Reaction to TNF: A Study of the TNFR1-Knockout Cell Model.
One of the mechanisms regulating the biological activity of tumor necrosis factor (TNF) in cells is the co-expression of TNFR1/TNFR2 receptors. A model with a differential level of receptor expression is required to evaluate the contribution of these mechanisms.Alina A Alshevskaya, Julia A Lopatnikova, Julia V Zhukova, Olga Y Perik-Zavodskaia, Saleh Alrhmoun, Irina A Obleukhova, Anna K Matveeva, Darya A Savenkova, Ilnaz R Imatdinov, Dmitry V Yudkin, Sergey V Sennikov
1778 related Products with: TNFR1 Absence Is Not Crucial for Different Types of Cell Reaction to TNF: A Study of the TNFR1-Knockout Cell Model.
100ug Lyophilized50 ug0.1ml (1mg/ml)100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100 μg100ug Lyophilized0.1ml (1mg/ml)100ug Lyophilized30 isolations
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#38650649 2024/04/19
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Discovery and validation of molecular patterns and immune characteristics in the peripheral blood of ischemic stroke patients.
Stroke is a disease with high morbidity, disability, and mortality. Immune factors play a crucial role in the occurrence of ischemic stroke (IS), but their exact mechanism is not clear. This study aims to identify possible immunological mechanisms by recognizing immune-related biomarkers and evaluating the infiltration pattern of immune cells.Lin Cong, Yijie He, Yun Wu, Ze Li, Siwen Ding, Weiwei Liang, Xingjun Xiao, Huixue Zhang, Lihua Wang
1273 related Products with: Discovery and validation of molecular patterns and immune characteristics in the peripheral blood of ischemic stroke patients.
10 mg50 ug 100ul6 inhibitors1000 TESTS/0.65ml10 mg
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#38649912 2024/04/22
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Investigating potential biomarkers of acute pancreatitis in patients with a BMI>30 using Mendelian randomization and transcriptomic analysis.
Acute pancreatitis (AP) has become a significant global health concern, and a high body mass index (BMI) has been identified as a key risk factor exacerbating this condition. Within this context, lipid metabolism assumes a critical role. The complex relationship between elevated BMI and AP, mediated by lipid metabolism, markedly increases the risk of complications and mortality. This study aimed to accurately define the correlation between BMI and AP, incorporating a comprehensive analysis of the interactions between individuals with high BMI and AP.Hua Ji, Zheng Tang, Kexin Jiang, Shuang Lyu, Yiwen Zhao, Jiajie Feng, Ruiwu Dai, Hongyin Liang
1159 related Products with: Investigating potential biomarkers of acute pancreatitis in patients with a BMI>30 using Mendelian randomization and transcriptomic analysis.
100 μg100 μg100ug100 μg100ug100 μg100 μg1 Set1 Set2.5 mg
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#38647454 2024/04/22
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A robust high-throughput functional screening assay for plant pathogen effectors using the TMV-GFP vector.
UPeng Cao, Haotian Shi, Shuangxi Zhang, Jialan Chen, Rongbo Wang, Peiqing Liu, Yingfang Zhu, Yuyan An, Meixiang Zhang
1024 related Products with: A robust high-throughput functional screening assay for plant pathogen effectors using the TMV-GFP vector.
400Tests100 assays4 Sample Kit100 assays100 assays100 tests1 kit(96 Wells)100 assays40 assays1 kit(96 Wells)
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#38646789 2024/04/22
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Sodium-glucose co-transporter 1 promotes the bio-functions of perivascular preadipocytes mediated by Akt/mTOR/p70S6K signaling pathway.
TZhiquan Liu, Jiayu Wang, Peiqing Tian, Yixuan Liu, Liyun Xing, Caihua Fu, Xianwei Huang, Ping Liu
1147 related Products with: Sodium-glucose co-transporter 1 promotes the bio-functions of perivascular preadipocytes mediated by Akt/mTOR/p70S6K signaling pathway.
100ug100ug100ug 100 G2.5 mg100 ml100 MG100ug2 Pieces/Box100ug1 mg100 ml
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#38646644 2024/03/25
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Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling.
It is poorly understood what cellular types participate in ductular reaction (DR) and whether DR facilitates recovery from injury or accelerates hepatic fibrosis. The aim of this study is to gain insights into the role of hepatic progenitor cell (HPC)-originated DR during fibrotic progression. DR in liver specimens of PBC, chronic HBV infection (CHB) or NAFLD, and four rodent fibrotic models by different pathogenic processes was evaluated. Gli1 expression was inhibited in rodent models or cell culture and organoid models by AAV-sh or treating with GANT61. Severity of liver fibrosis was positively correlated with DR extent in patients with PBC, CHB or NAFLD. HPCs were activated, expanded, differentiated into reactive cholangiocytes and constituted "HPC-originated DR", accompanying with exacerbated fibrosis in rodent models of HPC activation & proliferation (CCl/2-AAF-treated), spontaneous PSC, BDL-cholestatic fibrosis or WD-fed/CCl-treated NASH-fibrosis. Gli1 expression was significantly increased in enriched pathways and . Enhanced Gli1 expression was identified in KRT19-reactive cholangiocytes. Suppressing Gli1 expression by administration of AAV-sh or GANT61 ameliorated HPC-originated DR and fibrotic extent. KRT19 expression was reduced after GANT61 treatment in sodium butyrate-stimulated WB-F344 cells or organoids or in cells transduced with Gli1 knockdown lentiviral vectors. In contrast, KRT19 expression was elevated after transducing Gli1 overexpression lentiviral vectors in these cells. During various modes of chronic injury, Gli1 acted as an important mediator of HPC activation, expansion, differentiation into reactive cholangiocytes that formed DR, and subsequently provoked hepatic fibrogenesis.Yonghong Hu, Xinyu Bao, Zheng Zhang, Long Chen, Yue Liang, Yan Qu, Qun Zhou, Xiaoxi Zhou, Jing Fang, Zhun Xiao, Yadong Fu, Hailin Yang, Wei Liu, Ying Lv, Hongyan Cao, Gaofeng Chen, Jian Ping, Hua Zhang, Yongping Mu, Chenghai Liu, Chao-Po Lin, Jian Wu, Ping Liu, Jiamei Chen
2171 related Products with: Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling.
500 reactions1.5x10(6) cells24 reactions 4Inhibitors1.5 x 10^6 cells2 Pieces/Box6
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#38645872 //
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[Prokaryotic Expression and Bioinformatic Analysis of Rv3432c From ].
To express the protein enconded by the 3432 gene of (.) by prokaryotic expression, to analyze the structure of the Rv3432c protein by using bioinformatics software, and to explore for new drug targets against ..Haibo Yi, Xinghong Gao, Guo Luo, Peng Xu, Huan Wang