Only in Titles

           Search results for: SPAG9 _ JIP4 Control Peptide    

paperclip

#26291670   // Save this To Up

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

Cell cycle progression from G2 phase into mitosis is regulated by a complex network of mechanisms, all of which finally control the timing of Cyclin B/CDK1 activation. PLK1 regulates a network of events that contribute to regulating G2/M phase progression. Here we have used a proteomics approach to identify proteins that specifically bind to the Polobox domain of PLK1. This identified a panel of proteins that were either associated with PLK1 in G2 phase and/or mitosis, the strongest interaction being with the MAPK scaffold protein JIP4. PLK1 binding to JIP4 was found in G2 phase and mitosis, and PLK1 binding was self-primed by PLK1 phosphorylation of JIP4. PLK1 binding is required for JIP4-dependent p38MAPK activation in G2 phase during normal cell cycle progression, but not in either G2 phase or mitotic stress response. Finally, JIP4 is a target for caspase-dependent cleavage in mitotically arrested cells. The role for the PLK1-JIP4 regulated p38MAPK activation in G2 phase is unclear, but it does not affect either progression into or through mitosis.

1779 related Products with: JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

amyloid beta precursor pr zona pellucida binding pr Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In

Related Pathways

paperclip

#19211056   // Save this To Up

ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis.

Recent work has highlighted the importance of the recycling of endocytic membranes to the intercellular bridge for completion of cytokinesis in animal cells. ADP-ribosylation factor 6 (ARF6), which localizes to the plasma membrane and endosomal compartments, regulates endocytic recycling to the bridge during cytokinesis and is required for abscission.

2491 related Products with: ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis.

Homogenizer for 24 sample Head & Neck cancer test t Recombinant Human Interfe Cell Meter™ Fluorimetri Cell Meter™ Fluorimetri removed without changing ABT-263 Mechanisms: Bcl-2 ABT-737 Mechanisms: Bcl-2 AZD-6244 Mechanisms: MEK AZD-8055 Mechanisms: mTOR Crizotinib (PF-02341066) TAE-684 Mechanisms: ALK i

Related Pathways