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Vitamin D Status and Depressive Symptoms in Older Adults: A Role for Physical Functioning?

Depressive symptoms and low vitamin D status are common in older persons and may be associated, but findings are inconsistent. This study investigated whether 25-hydroxyvitamin D (25(OH)D) concentrations are associated with depressive symptoms in older adults, both cross-sectionally and longitudinally. We also examined whether physical functioning could explain this relationship, to gain a better understanding of the underlying mechanisms.

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The Association Between Vitamin D Level and Restless Legs Syndrome: A Population-Based Case-Control Study.

The pathophysiology of restless legs syndrome (RLS) may be related to abnormalities in central dopamine pathways. Vitamin D may play a role in the pathophysiology of RLS by modulating the dopaminergic system. The aim of our study is to examine the possible link between RLS and vitamin D deficiency.

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25(OH) vitamin D deficiency in lymphoid malignancies, its prevalence and significance. Are we fully aware of it?

Vitamin D has a role in cellular differentiation, proliferation, apoptosis, and angiogenesis and therefore is studied as a prognostic factor in cancer. The aim of our study was to assess the prevalence and significance of 25(OH)D deficiency in patients with lymphoid malignancies.

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Bioprocessing strategies for cost-effective large-scale biogenic synthesis of nano-MgO from endophytic Streptomyces coelicolor strain E72 as an anti-multidrug-resistant pathogens agent.

In this report, the local nano-MgO synthesizer strain has been isolated from Ocimum sanctum plant and deposited in GenBank as endophytic Streptomyces coelicolor strain E72. Its intracellular metabolic fraction that contains 7.2 μg/μl of carbohydrate, 6.3 g/l of protein and 5.2 nmol/hr/ml of nitrate reductase used to produce multi-surface shaped nano-MgO with diameter ~25 nm. To the best of our knowledge, this is the first report using statistical nanobiotechnological strategies (Plackett -Burman, Box-Behnken and Taguchi experimental designs) to study and evaluate the endophytic S. coelicolor biomass production (123.3 g/l) and extract the highest bioactive metabolites that used for biogenic synthesis of nano-MgO (320 g/l) through exponential sucrose pulses feeding fermentation strategy after 192 hr in semi industrial scale bioreactor (7 L). Purified nano-MgO applied in vitro against multi-drug resistant human pathogens and the large inhibition zone recorded against Shigella flexneri (108 ± 10.53 mm). The average of MICs was recorded as 25 µg/ml that inhibited 90% of the pathogenic living cells and compared with 100 mg/ml ampicilin/sulbactam solution that killed 40% of the same pathogen. These results are expected to gather sufficient knowledge to discover and develop a new cheap and eco-friendly nano-MgO as an extremely strong antimicrobial agent used in biomedical applications.

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Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis.

Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes.

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Undiagnosed Primary Hyperparathyroidism and Recurrent Miscarriage: The First Prospective Pilot Study.

Primary hyperparathyroidism (pHPT) in pregnancy is reported to be associated with significant maternal and foetal complications and an up to threefold increase in the risk of miscarriage. However, the true incidence of pHPT in pregnancy, complete and miscarried, is unknown and there are no data on the prevalence of undiagnosed pHPT in recurrent miscarriage (RM) (≥3 consecutive miscarriages under 24-week gestation). This is the first prospective study aiming to establish the prevalence of undiagnosed pHPT in RM.

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Serum Concentrations of 25-Hydroxyvitamin D and Depression in a General Middle-Aged to Elderly Population in Finland.

Low concentrations of serum 25-hydroxyvitamin D [25(OH)D] have been postulated to associate with an increased prevalence of depression. As there are a limited number of publications on this issue, we examined the association between serum 25(OH)D and depression in a general middle-aged or older population.

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Wavelength- and Temperature-Dependent Apparent Quantum Yields for Photochemical Production of Carbonyl Compounds in the North Pacific Ocean.

Photolysis of dissolved organic matter is the main source of carbonyl compounds in sunlit seawater, but rates and photoefficiences are poorly constrained. Wavelength- and temperature-dependent apparent quantum yields (AQYs) were determined for photochemical production of acetaldehyde, glyoxal, and methylglyoxal in North Pacific Ocean seawater. Wavelength-dependent AQYs at 20 °C decreased exponentially with increasing wavelength between 290 and 380 nm, from 1.29 × 10 to 4.12 × 10, 2.52 × 10 to 6.89 × 10, and 4.37 × 10 to 1.25 × 10 mol (mol quanta) for acetaldehyde, glyoxal, and methylglyoxal, respectively. AQYs decreased after 6 h irradiation at 310 nm, possibly due to depletion of photochemical precursors or carbonyl photolysis. Average activation energies (95% CI) for photochemical production at 320 nm were 9.31 (±9.3), 26.0 (±7.5), and 34.7 (±12.8) kJ mol for acetaldehyde, glyoxal, and methylglyoxal, respectively. The peak response for photochemical production rates in surface seawater was ∼325 nm, with ∼30% contribution from UV-B and ∼70% from UV-A. Computed noontime wavelength-integrated photoproduction rates were 0.5-0.8, 0.04-0.2, and 0.03-0.06 nmol L h for acetaldehyde, glyoxal, and methylglyoxal, respectively, under cloudless conditions in August. Results can be used to determine regional-scale photochemical production rates for these compounds in the surface ocean.

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Prevalence and possible factors associated with anaemia, and vitamin B and folate deficiencies in women of reproductive age in Pakistan: analysis of national-level secondary survey data.

To determine the prevalence and possible factors associated with anaemia, and vitamin B and folate deficiencies in women of reproductive age (WRA) in Pakistan.

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Usefulness of midregional pro-adrenomedullin as a marker of organ damage and predictor of mortality in patients with sepsis.

Midregional proadrenomedullin (MR-proADM) is a prognostic biomarker in patients with community-acquired pneumonia (CAP) and sepsis. In this paper, we examined the ability of MR-proADM to predict organ damage and long-term mortality in sepsis patients, compared to that of procalcitonin, C-reactive protein and lactate.

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