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#29684145   // Save this To Up

Effect of Roller Mill Configuration on Growth Performance of Nursery and Finishing Pigs and Milling Characteristics.

Three experiments were conducted to evaluate the effects of roller mill configuration on growth performance of nursery and finishing pigs, feed preference, and feed mill throughput. The 4 experimental treatments included corn ground through a roller mill using 2, 3, 4 sets of rolls in a fine grind configuration, or 4 sets of rolls in a coarse grind configuration. The same roller mill was used for all configurations with the appropriate lower rolls completely open when using the 2 or 3 roll pair configurations. Across all studies, mean particle size averaged approximately 540, 435, 270, and 385 µm for the 4 roller mill configurations, respectively. In Exp. 1, 320 pigs (DNA 400 × 200, initially 10.7 ± 0.27 kg BW) were randomly allotted to treatments with 5 pigs per pen and 16 pens per treatment in a 21-d growth trial. While there were no evidence of differences observed for ADG or ADFI, pigs fed corn ground using the 4-high coarse configuration had a marginally significant (P = 0.091) improvement in G:F compared to those fed with the 2-high configuration, with others intermediate. In Exp. 2, 90 pigs (PIC 327 × 1050, initially 12.1 ± 0.25 kg BW) were randomly allotted to 1 of 3 diet comparisons to determine feed preference between the 2-high, 4-high fine, and 4-high coarse configurations. When given a choice, pigs consumed more (P < 0.05) of the diet containing corn ground through the 2-high roller mill (67%) or 4-high coarse configuration (63%) compared to corn ground through the 4-high fine configuration. In Exp. 3, 922 finishing pigs (PIC TR4 × [FAST Large white × PIC Line 2], initially 40.1 ± 0.36 kg BW) were used in a 97-d experiment with pens of pigs randomly allotted by initial BW to the same experimental treatments used in Exp. 1. There were 21 pigs per pen and 11 pens per treatment. Pigs fed corn ground with the 2-high configuration had greater (P < 0.05) ADG compared to those fed corn ground using the 3-high configuration. Pigs fed corn ground with the 4-high fine configuration had the poorest (P < 0.05) ADG. No differences were observed in G:F. Grinding rate (tonne/h) was greatest (P < 0.05) for the 4-high coarse configuration, while net electricity consumption (kWh/tonne) was lowest (P < 0.05) for the 2-high configuration and greatest for the 4-high fine configuration. In summary, nursery pig G:F tended to be greatest using the 4-high coarse configuration, and finishing pig ADG was maximized using the 2 and 4-high coarse configurations.

1209 related Products with: Effect of Roller Mill Configuration on Growth Performance of Nursery and Finishing Pigs and Milling Characteristics.

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Biomimetic Beetle-Inspired Flapping Air Vehicle Actuated by Ionic Polymer-Metal Composite Actuator.

During the last decades, the ionic polymer-metal composite (IPMC) received much attention because of its potential capabilities, such as large displacement and flexible bending actuation. In this paper, a biomimetic flapping air vehicle was proposed by combining the superiority of ionic polymer metal composite with the bionic beetle flapping principle. The blocking force was compared between casted IPMC and IPMC. The flapping state of the wing was investigated and the maximum displacement and flapping angle were measured. The flapping displacement under different voltage and frequency was tested. The flapping displacement of the wing and the support reaction force were measured under different frequency by experiments. The experimental results indicate that the high voltage and low frequency would get large flapping displacement.

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CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP CRF Anti-Polyvalent HRP ELISA Kit for A Disinteg Mouse Anti-Human Matrix M Mouse Anti-Human Matrix M

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#29681821   // Save this To Up

Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease.

Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors. In both cases, we identified variants in 2 genes, and , indicative of the role of dysregulation of chromatin remodeling and cell cycle control as being common features of bladder cancer, consistent with the proposed model of tumorigenesis in these rare, highly aggressive pathological subtypes. The presence of a mutation in the poorly differentiated cancer and a 3 mutation in the sarcomatoid tumor is indicative of a distinctive profile and adds a potential layer of molecular stratification to these rarer histological subtypes. We present a comparative analysis of the histological, clinical, and molecular profile of both cases and discuss the potential to delineate these tumors at the molecular level keeping in mind the possible therapeutic implications.

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#29679996   // Save this To Up

Reactions to saline drinking water in Boer goats in a free-choice system.

Salinization of groundwater and soil is a prevalent global issue with serious consequences on animal health and production. The present study was conducted to investigate the capacity of Boer goats to adjust their salt intake from saline drinking water in a free-choice system. In total, 12 non-pregnant Boer goats aged between 1 and 8 years with an average BW of 46.4±8.3 kg were kept in individual pens for 4 weeks. In the control phase (1 week), only fresh water was supplied in five identical buckets for each pen. During the subsequent treatment phase (3 weeks), fresh water and four different concentrations (0.75, 1.0, 1.25 and 1.5% NaCl) of saline water were offered simultaneously in a free-choice system. The positions of the concentrations were changed daily at random. Cut hay and water were provided ad libitum, and a mineral supplement was allocated. Feed and water intake, mineral supplement intake, ambient temperature and relative humidity were recorded daily, whereas BW and body condition score were measured weekly. Dry matter intake, total water intake and total sodium intake were significantly (P<0.001) higher during the treatment phase. Body weight and body condition were not affected by saline water intake. Across the treatment phase, saline water consumption was significantly (P<0.001) lower in young (19.6±27.1 g/kg BW0.82 per day) than in adult goats (27.9±31.5 g/kg BW0.82 per day), indicating that young goats were more sensitive towards the saline water. All goats had a significant preference for fresh water (0% salt) over saline water. At the first offering of the simultaneous choice situation (week 2), animals did not differentiate between the salt concentration of 0.75% and 1.0%. However, with successive treatment (weeks 3 and 4), animals distinguished between saline water concentrations and preferred the 0.75% salt concentration. Salt concentrations of 1% to 1.5% were avoided. The total sodium intake of the goats ranged between 0.37 and 0.55 g /kg BW0.75 per day during the treatment phase, being 8- to 11-fold higher than the daily requirements of sodium for body maintenance. The results suggest that goats are able to differentiate between saline water concentrations and to adjust their sodium intake by quick adjustments in self-selection in a free-choice system. Compared with two-choice preference tests, the present free-choice situation allows evaluating changes in saline water acceptance with prolonged exposure.

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Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction.

The demand for highly efficient macromolecular drugs, used in the treatment of many severe diseases, is continuously increasing. However, the hydrophilic character and large molecular size of these drugs significantly limit their ability to permeate across cellular membranes and thus impede the drugs in reaching their target sites in the body. Cell-penetrating peptides (CPP) have gained attention as promising drug excipients, since they can facilitate drug permeation across cell membranes constituting a major biological barrier. Fluorophores are frequently covalently conjugated to CPPs to improve detection, however, the ensuing change in physico-chemical properties of the CPPs may alter their biological properties. With complementary biophysical techniques, we show that the mode of biomembrane interaction may change considerably upon labeling of the CPP penetratin (PEN) with a fluorophore. Fluorophore-PEN conjugates display altered modes of membrane interaction with increased insertion into the core of model cell membranes thereby exerting membrane-thinning effects. This is in contrast to PEN, which localizes along the head groups of the lipid bilayer, without affecting the thickness of the lipid tails. Particularly high membrane disturbance is observed for the two most hydrophobic PEN conjugates; rhodamine B or 1-pyrene butyric acid, as compared to the four other tested fluorophore-PEN conjugates.

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Cell Navigator™ F Actin Cell Navigator™ F Actin Cell Navigator™ F Actin Cell Navigator™ F Actin AMC [7 Amino 4 methylcoum AMC [7 Amino 4 methylcoum AFC [7 Amino 4 trifluorom AFC [7 Amino 4 trifluorom MarkerGeneTM TAMRA Antibo 4 ((4 (dimethylamino)phen 7 Diethylaminocoumarin 3 MarkerGene™ LysoLive™

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The effect of n-6/n-3 fatty acid ratios on broiler breeder performance, hatchability, fatty acid profile and reproduction.

This experiment was conducted to study the effect of dietary omega6 (n-6) to omega3 (n-3) fatty acid (FA) ratios on performance and reproduction of broiler breeders. In experiment 1, 400 females and 40 males (30 week age) of Ross 308 broiler breeder (20 females and two males in each pen) were randomly assigned to one of the four diets with n-6/n-3 FA ratios of 4, 6, 8 and 16 (control). As a measure of hatchability, fertility of eggs and general incubation traits, 1,200 eggs (60 eggs from each pen) were collected and incubated for 21 days and embryo liver and brain fatty acid profile in 14 and 21 days were determined. In experiment 2, 48 males (three males in each pen) randomly assigned to one of the four diets with n-6/n-3 FA ratios of 4, 6, 8 and 16 (control). Semen was collected twice weekly, and semen volume, spermatozoa concentration and motility and alive and dead spermatozoa were estimated. Egg production and egg mass were decreased by n-6/n-3 FA ratios of 4:1 and 6:1 (p < .05). There were no significant differences between treatments on breeder's body weight, eggs fertility and hatchability, embryonic mortality and semen features. Linolenic acid, eicosapentaenoic acid, docosahexaenoic acid and total n-3 of egg yolk, semen, testis and liver and brain of embryo and day-old chicken were increased while concentration of linoleic acid, arachidonic acid and docosatetraenoic acid of mentioned tissues were decreased by increasing n-6/n-3 FA ratios (p > .05). In conclusion, absolute amount of n-3 and n-6 FAs in broiler breeder diet may be more important than n-6/n-3 FA ratios and to consider reproductive and performance traits of breeders, it is necessary to supply higher levels of n-3 and n-6 FA with respect to n-6/n-3 FA ratios.

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The Relationship Between Sensorimotor and Handwriting Performance in Chinese Adolescents with Autism Spectrum Disorder.

Impaired sensorimotor control, as a common feature of autism spectrum disorder (ASD), could be a driving factor to handwriting problems. This study examined the Chinese and English handwriting and sensorimotor skills of 15 ASD and 174 typically developing Chinese adolescents. Participants with ASD had lower writing speed and poor manual dexterity (MD) than the typically developing participants. MD was a significant mediator between ASD and handwriting speed. Ground time and airtime represent the length of time when the pen touches the paper and is held in air, respectively. Participants with ASD who had better performance in MD showed shorter ground time in Chinese handwriting and shorter airtime in English handwriting. Training for adolescents with ASD on their MD may improve their handwriting performance.

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Liver disease spectrum ti Lung disease spectrum tis Colon disease spectrum ti Rectum disease spectrum ( Kidney disease spectrum ( Breast disease spectrum t Breast disease spectrum t Breast disease spectrum t Thermal Shaker with cooli Cervical intraepithelial Brain disease spectrum (b Colon disease spectrum (c

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European seabass respond more strongly to noise exposure at night and habituate over repeated trials of sound exposure.

Aquatic animals live in an acoustic world, prone to pollution by globally increasing noise levels. Noisy human activities at sea have become widespread and continue day and night. The potential effects of this anthropogenic noise may be context-dependent and vary with the time of the day, depending on diel cycles in animal physiology and behaviour. Most studies to date have investigated behavioural changes within a single sound exposure session while the effects of, and habituation to, repeated exposures remain largely unknown. Here, we exposed groups of European seabass (Dicentrarchus labrax) in an outdoor pen to a series of eight repeated impulsive sound exposures over the course of two days at variable times of day/night. The baseline behaviour before sound exposure was different between day and night; with slower swimming and looser group cohesion observed at night. In response to sound exposures, groups increased their swimming speed, depth, and cohesion; with a greater effect during the night. Furthermore, groups also showed inter-trial habituation with respect to swimming depth. Our findings suggest that the impact of impulsive anthropogenic noise may be stronger at night than during the day for some fishes. Moreover, our results also suggest that habituation should be taken into account for sound impact assessments and potential mitigating measures.

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Evaluation of potential antioxidant and anti-inflammatory effects of Antrodia cinnamomea powder and the underlying molecular mechanisms via Nrf2- and NF-κB-dominated pathways in broiler chickens.

Antrodia cinnamomea, a precious and unique medical fungus existing exclusively in Taiwan, exhibits antioxidant and immunomodulatory properties. This study was conducted to evaluate the beneficial effects of A. cinnamomea powder (ACP) and to further illuminate its underlying antioxidant and immunomodulation molecular mechanisms in broilers. The functional compounds of ACP-crude triterpenoids, crude polysaccharides, and total phenolic content-were assayed, respectively. Two-hundred-forty one-day-old broilers (Ross 308) were assigned to 4 treatment groups receiving dietary supplementation with ACP at 0, 0.1, 0.2, and 0.4% for 35 days. Each group had 4 replicate pens, with 15 birds per pen. During 1 to 21- and 22 to 35-day periods, chickens on ACP-supplemented diet demonstrated increased body weight gain, compared to those on the control diet, resulting in increased weight gain throughout the entire experimental period with an increased tendency in feed consumption yet no significant difference in FCR. Blood antioxidant potentiality, superoxide dismutase (SOD), increased in birds fed the supplemented diet at both 21 and 35 d, accompanied by higher catalase (CAT) activity at 21 days. In vivo peripheral blood mononuclear cells (PBMC) exposed to lipopolysaccharide (LPS) and 2,2΄-Azobis(2-amidinopropane) dihydrochloride (AAPH) capability showed that the diminished cell viability caused by both challenge factors was improved in ACP-supplemented groups. Antioxidant genes dominated by Nrf2 genes, such as HO-1 and GCLC, were up-regulated in 35-day-old birds. Inflammatory-related genes, such as IL-1β and IL-6, ruled mainly by NF-κB, were rather down-regulated by 0.2% ACP addition at 21 and 35 days. Protein expression of Nrf2 and NF-κB in the liver supported the mRNA results, demonstrating that all ACP-supplemented groups showed significantly higher Nrf2 expression, whereas the NF-κB was inhibited. In conclusion, preferable microbial balance may putatively indicate the improvement of immunomodulatory-related capacity by ACP. Furthermore, ACP could induce the Nrf2-dependent pathway and decrease the NF-κB-dominated inflammatory signaling pathway. Antioxidant and immune capacity in terms of antioxidant enzymes and cell tolerance also was elevated by ACP. Concomitantly, body weight increasing with ACP supplementation as compared to the corresponding control group further implied the promising effects exerted by ACP.

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Rabbit Anti-Human Androge Rabbit Anti-Human Androge AZD-3514 Mechanisms: Andr Rabbit Anti-Human Androge Goat Anti-Human Androgen Rabbit Anti-Rat Androgen Rabbit anti Androgen Rece Anti-Androgen Receptor pr Anti Androgen Receptor pr Androgen Receptor (Phosph Androgen Receptor (Phosph anti H inh human blood an

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Formative usability evaluation of a fixed-dose pen-injector platform device.

This article for the first time presents a formative usability study of a fixed-dose pen injector platform device used for the subcutaneous delivery of biopharmaceuticals, primarily for self-administration by the patient. The study was conducted with a user population of both naïve and experienced users across a range of ages. The goals of the study were to evaluate whether users could use the devices safely and effectively relying on the instructions for use (IFU) for guidance, as well as to benchmark the device against another similar injector established in the market. Further objectives were to capture any usability issues and obtain participants' subjective ratings on the properties and performance of both devices.

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