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#31341471   2019/06/24 To Up

Aberrant Histone Methylation in Patients with Graves' Disease.

Graves' disease (GD) is an organ-specific autoimmune disease. Accumulated data have indicated that aberrant epigenetic modifications are associated with many autoimmune disorders. However, it remains unknown whether histone methylation plays a role in the pathogenesis of GD. In the present study, we aimed to assess histone modification patterns in peripheral blood mononuclear cells (PBMCs) from GD patients. The rate (degree) of H3K4 and H3K9 methylation and the expressions of histone-modifying genes were investigated.
Ni Yan, Kaida Mu, Xiao-Fei An, Ling Li, Qiu Qin, Rong-Hua Song, Qiu-Ming Yao, Xiao-Qing Shao, Jin-An Zhang

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