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In colonic ρ(rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer.

Mitochondrial reprogramming has emerged as a hallmark of cancer pathobiology. Although it is believed this reprogramming is essential for cancer cells to thrive, how it supports cancer pathobiology is unclear. We previously generated colonic ρ0 (rho0) cells with reduced mitochondrial energy function and acquired their transcriptional signature. Here, we utilized a bioinformatics approach to identify their changes linked to cancer pathobiology.

2251 related Products with: In colonic ρ(rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer.

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A simulation study on implementing marginal structural models in an observational study with switching medication based on a biomarker.

Assessing treatment effectiveness in longitudinal data can be complex when treatments are not randomly assigned and patients are allowed to switch treatment to other or no treatment, often in a manner that is driven by changes in one or more variables associated with patient or clinical characteristics. There can be confounding of the treatment effect from a time-varying variable, i.e., one which is affected by previous exposure and can in turn also influence subsequent treatment changes. Precision medicine relies on validated biomarkers to better classify patients by their probable response to treatment. However, biomarkers may be a source of time-varying confounding, which are affected by prior treatment in the evaluation and are also subject to measurement errors. The impact of switching medications based on a biomarker has received less attention. We conducted simulation studies to explore biased estimation under various scenarios when marginal structural model estimations are employed. Holding model misspecification issues constant, bias is severe in the presence of multiple switching, along with measurement error and missing data in the covariates.

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Toxic metals in amniotic fluid and altered gene expression in cell-free fetal RNA.

Both exposures to toxic metals, as well as deficiencies in essential metals, during pregnancy has been linked to a variety of negative reproductive outcomes. The exact etiologies of such outcomes and the effects of fetal exposure to these metals are largely unknown. Therefore, the ability to assess levels of these elements is critical to determining the underlying causes of such conditions and the effects that both essential and nonessential metals have on fetal development. Thus, using cell-free fetal RNA from amniotic fluid, we set out to measure the association between amniotic fluid levels of toxic and essential metals and fetal gene expression. We find that arsenic was associated with increased expression of 3 genes known to play roles in both birth-related and reproductive effects. The results highlight the potential for detrimental health effects of prenatal metals exposure and the potential to identify biomarkers of environmental exposure during this critical developmental period.

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HYPERHOMOCYSTEINEMIA AS A PREDICTOR OF CARDIOVASCULAR DISEASES IN LEAD-EXPOSED SUBJECTS.

Homocysteine is independent risk factors for the development of cardiovascular diseases, such as atherosclerosis and hypertension. Therefore, the aim of our study was to establish the relationship between the concentration of lead in the blood of patients who were in contact with this heavy metal at work and clinical manifestations. The subjects of the study were 203 men 38 to 47 years old. The main group consisted of 146 people who were in direct contact with lead at work (cable network repair), the control group was 57 people (engineers and technicians). The contents of homocysteine were determined in blood serum using reagents for the enzyme immunoassay "AXIS-SHIELD" (Norway), according to the manufacturer's method. The database in the Microsoft Excel 2007 format was used to collect and process the results of the studies. The criteria for both parametric and nonparametric statistics were used to process the metrics using Statistica for Windows 6.0 software (Statsoft In., USA). The increase in the level of lead in their blood was observed in all patients with clinical manifestations of cardiovascular diseases. They were divided into 3 main groups: I - the amount of lead in the blood 2.12±0.013 μmol/l; II - 2.12±0.013 μmol/l; III - 1.72±0.028 μmol/l. The changes in clinical features that were obtained had the highest values for workers in the group with the highest homocysteine level in their blood (18.32±0.9 μmol/l), which exceeded the values of apparently healthy subjects (10.22±0.56 μmol/l) in 1.79 times. The minimum level of homocysteine in the blood was found in workers of group III, who had only isolated symptoms of development of asthenic - vegetative syndrome (an increase in the level of homocysteine was minimal - 12.2±0.41 μmol/l). The existence of a relationship between the content of lead in blood and the level of homocysteine is confirmed by positive correlation between the indices. So, in workers exposed to lead, the serum homocysteine content is exceeded in direct proportion to the increase in lead in the blood, which can be regarded as an independent risk factor (marker) for the development of cardiovascular pathology.

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Virulence traits associated withST856 epidemic strain isolated from cystic fibrosis patients.

is considered one of the most problematic cystic fibrosis (CF) pathogens. Colonization prevalence in the Serbian CF population is high and virtually exclusively limited to a single highly transmissible clone ofST856 which is positive for both theepidemic strain marker (BCESM) and cable pilin, and is closely related to the epidemic strain CZ1 (ST32).

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Modeling the response of small myelinated axons in a compound nerve to kilohertz frequency signals.

There is growing interest in electrical neuromodulation of peripheral nerves, particularly autonomic nerves, to treat various diseases. Electrical signals in the kilohertz frequency (KHF) range can produce different responses, including conduction block. For example, EnteroMedics' vBloctherapy for obesity delivers 5 kHz stimulation to block the abdominal vagus nerves, but the mechanisms of action are unclear.

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Overexpression of Transforming Acidic Coiled Coil‑Containing Protein 3 Reflects Malignant Characteristics and Poor Prognosis of Glioma.

Gliomas are malignant primary brain tumors with poor prognosis. Recently, research was indicative of a tight connection between tumor malignancy and genetic alterations. Here, we propose an oncogenic implication of transforming acidic coiled-coil-containing protein 3 (TACC3) in gliomas. By comprehensively analyzing the Chinese glioma genome atlas (CGGA) and publicly available data, we demonstrated that TACC3 were overexpressed along with glioma grade and served as an independent negative prognostic biomarker for glioma patients. Functions' annotations and gene sets' enrichment analysis suggested that TACC3 may participate in cell cycle, DNA repair, epithelium-mesenchymal transition and other tumor-related biological processes and molecular pathways. Patients with high TACC3 expression showed CD133⁺ stem cell properties, glioma plasticity and shorter overall survival time under chemo-/radio-therapy. Additionally, a TACC3 associated the miRNA-mRNA network was constructed based on in silico prediction and expression pattern, which provide a foundation for further detection of TACC3-miRNA-mRNA axis function. Collectively, our observations identify TACC3 as an oncogene of tumor malignancy, as well as a prognostic and motoring biomarker for glioma patients.

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The feasibility of using Microsoft Kinect v2 sensors during radiotherapy delivery.

Consumer-grade distance sensors, such as the Microsoft Kinect devices (v1 and v2), have been investigated for use as marker-free motion monitoring systems for radiotherapy. The radiotherapy delivery environment is challenging for such sen-sors because of the proximity to electromagnetic interference (EMI) from the pulse forming network which fires the magnetron and electron gun of a linear accelerator (linac) during radiation delivery, as well as the requirement to operate them from the control area. This work investigated whether using Kinect v2 sensors as motion monitors was feasible during radiation delivery. Three sensors were used each with a 12 m USB 3.0 active cable which replaced the supplied 3 m USB 3.0 cable. Distance output data from the Kinect v2 sensors was recorded under four condi-tions of linac operation: (i) powered up only, (ii) pulse forming network operating with no radiation, (iii) pulse repetition frequency varied between 6 Hz and 400 Hz, (iv) dose rate varied between 50 and 1450 monitor units (MU) per minute. A solid water block was used as an object and imaged when static, moved in a set of steps from 0.6 m to 2.0 m from the sensor and moving dynamically in two sinusoidal-like trajectories. Few additional image artifacts were observed and there was no impact on the tracking of the motion patterns (root mean squared accuracy of 1.4 and 1.1mm, respectively). The sensors' distance accuracy varied by 2.0 to 3.8 mm (1.2 to 1.4 mm post distance calibration) across the range measured; the precision was 1 mm. There was minimal effect from the EMI on the distance calibration data: 0 mm or 1 mm reported distance change (2 mm maximum change at one position). Kinect v2 sensors operated with 12 m USB 3.0 active cables appear robust to the radiotherapy treatment environment.

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Transcriptomic resources and marker validation for diploid and polyploid(Plantaginaceae) from New Zealand and Europe.

Polyploidy may generate novel variation, leading to adaptation and species diversification. An excellent natural system to study polyploid evolution in a comparative framework is(Plantaginaceae), which comprises several parallel, recently evolved polyploid series.

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Association Between Single Gene Polymorphisms and Bone Biomarkers and Response to Calcium and Vitamin D Supplementation in Young Adults Undergoing Military Training.

Initial military training (IMT) is associated with increased stress fracture risk. In prior studies, supplemental calcium (Ca) and vitamin D provided daily throughout IMT reduced stress fracture incidence, suppressed parathyroid hormone (PTH), and improved measures of bone health compared with placebo. Data were analyzed from a randomized, double-blind, placebo-controlled trial to determine whether single-nucleotide polymorphisms (SNPs) in Ca and vitamin D-related genes were associated with circulating biomarkers of bone metabolism in young adults entering IMT, and whether responses to Ca and vitamin D supplementation were modulated by genotype. Associations between SNPs, including vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-alpha-hydroxylase (CYP27B1), and circulating biomarkers were measured in fasting blood samples from volunteers (n = 748) starting IMT. Volunteers were block randomized by race and sex to receive Ca (2000 mg) and vitamin D (1000 IU) or placebo daily throughout Army or Air Force IMT (7 to 9 weeks). Total Ca and vitamin D intakes were calculated as the sum of supplemental intake based on intervention compliance and dietary intake. Relationships between SNPs, Ca, and vitamin D intake tertile and change in biomarkers were evaluated in trial completers (n = 391). At baseline, the minor allele of a DBP SNP (rs7041) was positively associated with both 25OHD (B = 4.46, p = 1.97E-10) and 1,25(OH)D(B = 9.63, p < 0.001). Combined genetic risk score (GRS) for this SNP and a second SNP in the VDR gene (rs1544410) was inversely associated with baseline 25OHD (r = -0.28, p < 0.001) and response to Ca and vitamin D intake differed by GRS (p < 0.05). In addition, presence of the minor allele of a second VDR SNP (rs2228570) was associated with lower P1NP (B = -4.83, p = 0.04) and osteocalcin (B = -0.59, p = 0.03). These data suggest that VDR and DBP SNPs are associated with 25OHD status and bone turnover and those with the highest GRS require the greatest vitamin D intake to improve 25OHD during IMT. © 2016 American Society for Bone and Mineral Research.

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