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Effects of thioamide substitution for the enkephalin conformation. Crystal structure of Boc-Tyr-Gly-Gly-Phe psi [CSNH]Leu-OBzl.

The crystals of Boc-Tyr-Gly-Gly-Phe psi[CSNH]Leu-OBzl monohydrate (C40H51N5O8S.H2O), a monothionated Leu-enkephalin analogue, were obtained with space group P2(1), a = 12.616(3), b = 9.347(2), c = 18.548(5) A, beta = 96.31(4) degrees. The structure was elucidated by X-ray diffraction analysis, and refined to the R value of 0.091 for the observed 3294 reflections. Two antiparallel molecules related by a pseudo twofold symmetry were stabilized to each other by four intermolecular hydrogen bonds. The molecular conformation was bent at the Phe residue, and the extended moiety of the Tyr-Gly-Gly fragment was almost perpendicular to that of the Phe-Leu residues. Consequently the molecule, as a whole, formed an L-shape conformation with a slightly left-handed helicity.
M Doi, S Takehara, T Ishida, M Inoue

2743 related Products with: Effects of thioamide substitution for the enkephalin conformation. Crystal structure of Boc-Tyr-Gly-Gly-Phe psi [CSNH]Leu-OBzl.

5 G12.5 mg100 MG 25 G 5 G50 assays6 x 50 µl 100 MG 25 G100μg

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