Irinotecan, Hydrochloride Salt, Trihydrate productsSearch results for: Irinotecan, Hydrochloride Salt, Trihydrate
#27871319 
2016/11/21
To Up
A phase I dose-escalation study of PEP02 (irinotecan liposome injection) in combination with 5-fluorouracil and leucovorin in advanced solid tumors.
PEP02 (also known as MM-398, nal-IRI) is a novel nanoparticle formulation of irinotecan encapsulated in liposomes. The aims of this study were to investigate the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) and pharmacokinetics (PK) of PEP02 in combination with 5-FU and LV, in patients with advanced refractory solid tumors.Nai-Jung Chiang, Tsu-Yi Chao, Ruey-Kuen Hsieh, Cheng-Hsu Wang, Yi-Wen Wang, C Grace Yeh, Li-Tzong Chen
