Search results for: Human CYP26A1 control_blocking peptide 1
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MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro.Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by an increased risk of malignant peripheral nerve sheath tumors (MPNST). Chemotherapy of MPNST is still insufficient. In this study, we investigated whether human tumor Schwann cells derived from NF1 associated MPNST respond to all-trans retinoic acid (ATRA). We analyzed effects of ATRA and MEK inhibitor (MEKi) combination therapy.
2068 related Products with: MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro.Rat TGF-beta-inducible ea Rat TGF-beta-inducible ea Anti beta3 AR Human, Poly Cultrex In Vitro Angiogen AS-703026 Mechanisms: MEK AZD-6244 Mechanisms: MEK RDEA-119 (BAY-869766) Mec CI-1040 (PD184352) Mechan RO-5126766 Mechanisms: Ra MEK-162 (ARRY-438162) Mec PLX-4032 Mechanisms: B-Ra PLX-4720 Mechanisms: B-Ra
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Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance.Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events to prevent differentiation and confer resistance.
2238 related Products with: Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance.TGF beta induced factor 2 (αR,βS)-β-(Acetylamino (2S)-2-Amino-benzenebutan (αS,βS)-β-[(2-Aminophe Androst-4-ene-3,17-dion-1 (1R,3S,5R)-2-Azabicyclo[3 Polyclonal anti conjugate ENZYMATIC ASSAY KITS (CH LIVER DISEASES Total Bile LIVER DISEASES Total Bile CAR,CAR,Constitutive acti 6 para Toluidino 2 naphth
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Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema.Molecular pathways that regulate alveolar development and adult repair represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA), derived from vitamin A, is required for mammalian alveologenesis, and exogenous RA can induce alveolar regeneration in rodents. Little is known about RA signalling in the human lung and its potential role in lung disease.
1635 related Products with: Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema.Recombinant Human Interfe Angiogenesis (Human) Anti Angiogenesis (Human) Anti Angiogenesis (Human) Anti Angiogenesis (Human) Anti Goat Anti-Human TOM1L1 SR Rabbit Anti-Human Toll In Total RNA Human Adult Nor Top 4 types of cancer (co Top 4 types of cancer (co Brain-Specific Angiogenes Brain Specific Angiogenes
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Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells.Polyamidoamine (PAMAM) dendrimers have potential for biological applications as delivery systems for genes, drugs, and imaging agents into the brain, but their developmental neurotoxicity remains unknown. We investigated the effects of PAMAM dendrimers with various surface functional groups and multiple generations on neuronal differentiation using human neural progenitor cells at an equal mass concentration. Only PAMAM dendrimers containing amine (NH2) surface groups at concentrations of 10 μg/mL significantly reduced cell viability and neuronal differentiation, compared with non-amine-terminated dendrimers. PAMAM-NH2 with generation (G)3, G4, G5 G6, and G7 significantly decreased cell viability and inhibited neuronal differentiation from a concentration of 5 μg/mL, but G0, G1, and G2 dendrimers did not have any effect at this concentration. Cytotoxicity indices of PAMAM-NH2 dendrimers at 10 μg/mL correlated well with the zeta potentials of the particles. Surface group density and particle number in unit volume is more important characteristic than particle size to influence cytotoxicity for positive changed dendrimers. PAMAM-50% C12 at 1 μg/mL altered the expression level of the oxidative stress-related genes, ROR1, CYP26A1, and TGFB1, which is a DNA damage response gene. Our results indicate that PAMAM dendrimer exposure may have a surface charge-dependent adverse effect on neuronal differentiation, and that the effect may be associated with oxidative stress and DNA damage during development of neural cells.
2570 related Products with: Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells.Epidermal Growth Factor ( Epidermal Growth Factor ( Rabbit Anti-Human Androge Rabbit Anti-Human Androge Rabbit Anti-Human Androge Goat Anti-Human Androgen CAR,CAR,Constitutive acti STEMEZ™ hNP1 Human Neur Mouse Anti-Human CD34 Tar Recombinant Human Androge Anti C Reactive Protein A anti HBsAg pre surface Ig
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β-Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats.We studied β-carotene (BC) absorption and metabolism and compared BC and retinyl palmitate (RE) for their impact on white adipose tissue (WAT) development in suckling rats.
2356 related Products with: β-Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats.Alkaline Phospatase (ALP) FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu GI cancer (esophageal, ga Triglyceride Assay Kit Li α-Acetamino-α-carboxy-( 3-O-Acetyl-17-O-tert-buty Androst-4-ene-3,17-dion-1 Polyclonal anti conjugate (4R,5S)-3-N-Benzyl-4-(t-b
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Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.The meiotic program initiation pathway genes (CYP26B1, NANOS1 and STRA8) have been proposed to play key roles in spermatogenesis.
2627 related Products with: Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.Goat Anti-Human, Mouse AR Primary antibody FLIP An Apoptosis antibody array Cell cycle antibody array Cytokine antibody array i Signal transduction antib AKT Phospho-Specific Arra AKT PKB Signaling Phospho AMPK Signaling Phospho-Sp Cancer Apoptosis Phospho- Cell Cycle Phospho-Specif Chromatin Transcription P
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Mass spectrometry-based proteomic analysis of human liver cytochrome(s) P450.The major objective of personalized medicine is to select optimized drug therapies and to a large degree such mission is determined by the expression profiles of cytochrome(s) P450 (CYP). Accordingly, a proteomic case study in personalized medicine is provided by the superfamily of cytochromes P450. Our knowledge about CYP isozyme expression on a protein level is very limited and based exclusively on DNA/mRNA derived data. Such information is not sufficient because transcription and translation events do not lead to correlated levels of expressed proteins. Here we report expression profiles of CYPs in human liver obtained by mass spectrometry (MS)-based proteomic approach. We analyzed 32 samples of human liver microsomes (HLM) of different sexes, ages and ethnicity along with samples of recombinant human CYPs. We have experimentally confirmed that each CYP isozyme can be effectively differentiated by their unique isozyme-specific tryptic peptide(s). Trypsin digestion patterns for almost 30 human CYP isozymes were established. Those findings should assist in selecting tryptic peptides suitable for MS-based quantitation. The data obtained demonstrate remarkable differences in CYP expression profiles. CYP2E1, CYP2C8 and CYP4A11 were the only isozymes found in all HLM samples. Female and pediatric HLM samples revealed much more diverse spectrum of expressed CYPs isozymes compared to male HLM. We have confirmed expression of a number of "rare" CYP (CYP2J2, CYP4B1, CYP4V2, CYP4F3, CYP4F11, CYP8B1, CYP19A1, CYP24A1 and CYP27A1) and obtained first direct experimental data showing expression of such CYPs as CYP2F1, CYP2S1, CYP2W1, CYP4A22, CYP4X1, and CYP26A1 on a protein level.
1408 related Products with: Mass spectrometry-based proteomic analysis of human liver cytochrome(s) P450.Cytochrome P450 4A11 anti Human Cytochrome P450 2D6 Resorufin 7 O methyl ethe Cytochrome P450 2C9 Cytochrome P450 3A4 Mouse Anti-Human Liver Ag Rabbit Anti-Human Cytochr Rabbit Anti-Human Cytochr cytochrome c oxidase subu ubiquinol-cytochrome c re ubiquinol-cytochrome c re Pyruvate Kinase(liver RBC
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Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies.We conducted a population-based case-control study of single nucleotide polymorphisms (SNPs) in selected genes to find common variants that play a role in the etiology of limb deficiencies (LDs). Included in the study were 389 infants with LDs of unknown cause and 980 unaffected controls selected from all births in New York State (NYS) for the years 1998-2005. We used cases identified from the NYS Department of Health (DOH) Congenital Malformations Registry. Genotypes were obtained for 132 SNPs in genes involved in limb development (SHH, WNT7A, FGF4, FGF8, FGF10, TBX3, TBX5, SALL4, GREM1, GDF5, CTNNB1, EN1, CYP26A1, CYP26B1), angiogenesis (VEGFA, HIF1A, NOS3), and coagulation (F2, F5, MTHFR). Genotype call rates were >97% and SNPs were tested for departure from Hardy-Weinberg expectations by race/ethnic subgroups. For each SNP, odds ratios (OR)s and confidence intervals (CI)s were estimated and corrected for multiple comparisons for all LDs combined and for LD subtypes. Among non-Hispanic white infants, associations between FGF10 SNPs rs10805683 and rs13170645 and all LDs combined were statistically significant following correction for multiple testing (OR = 1.99; 95% CI = 1.43-2.77; uncorrected P = 0.000043 for rs10805683 heterozygous genotype, and OR = 2.37; 95% CI = 1.48-3.78; uncorrected P = 0.00032 for rs13170645 homozygous minor genotype). We also observed suggestive evidence for associations with SNPs in other genes including CYP26B1 and WNT7A. Animal studies have shown that FGF10 induces formation of the apical ectodermal ridge and is necessary for limb development. Our data suggest that common variants in FGF10 increase the risk for a wide range of non-syndromic limb deficiencies.
1425 related Products with: Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies.Directed In Vivo Angiogen Cultrex In Vitro Angiogen Cultrex In Vitro Angiogen Endothelial Tube Formatio Mouse Anti-Insulin-Like G DNA (cytosine 5) methyltr EMAP-II Inhibitor Z-ASTD- EMAP-II Inhibitor Z-ASTD- EMAP II Inhibitor Z ASTD EMAP II Inhibitor Z ASTD Amplite™ Fluorimetric H Amplite™ Intracellular
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Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes.Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) function and receptor cross-talk with other nuclear receptors, including PPARγ and retinoic acid receptors (RARs), was examined using stable human HaCaT keratinocyte cell lines over-expressing PPARβ/δ or PPARγ. Enhanced ligand-induced expression of two known PPAR target genes, adipocyte differentiation-related protein (ADRP) and angiopoietin-like protein 4 (ANGPTL4), was found in HaCaT keratinocytes over-expressing PPARβ/δ or PPARγ. Over-expression of PPARβ/δ did not modulate the effect of a PPARγ agonist on up-regulation of ADRP or ANGPTL4 mRNA in HaCaT keratinocytes. All-trans retinoic acid (atRA) increased expression of a known RAR target gene, yet despite a high ratio of fatty acid binding protein 5 (FABP5) to cellular retinoic acid binding protein II, did not increase expression of ANGPTL4 or 3-phosphoinositide-dependent-protein kinase 1 (PDPK1), even in HaCaT keratinocytes expressing markedly higher levels of PPARβ/δ. While PPARβ/δ-dependent attenuation of staurosporine- or UVB-induced poly (ADP-ribose) polymerase (PARP) cleavage was not observed, PPARβ/δ- and PPARγ-dependent repression of UVB-induced expression and secretion of inflammatory cytokines was found in HaCaT keratinocytes over-expressing PPARβ/δ or PPARγ. These studies suggest that FABP5 does not transport atRA or GW0742 to PPARβ/δ and promote anti-apoptotic activity by increasing expression of PDPK1, or that PPARβ/δ interferes with PPARγ transcriptional activity. However, these studies demonstrate that stable over-expression of PPARβ/δ or PPARγ significantly increases the efficacy of ligand activation and represses UVB-induced expression of tumor necrosis factor α (TNFα), interleukin 6 (IL6), or IL8 in HaCaT keratinocytes, thereby establishing an excellent model to study the functional role of these receptors in human keratinocytes.
2063 related Products with: Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes.Interferon-a Receptor Typ Mouse Anti-Human Interleu Rabbit Anti-Human Androge Rabbit Anti-Human Androge interleukin 17 receptor C Recombinant Human Interfe interferon-alpha receptor Human integrin aVb3, affi IGF-1R Signaling Phospho- T-Cell Receptor Signaling Human T Cell Receptor Sig Human soluble interleukin
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Cytokine-related genes and oxidation-related genes detected in preeclamptic placentas.To investigate cytokine- and oxidation-related genes for preeclampsia using DNA microarray analysis.
1948 related Products with: Cytokine-related genes and oxidation-related genes detected in preeclamptic placentas.Apoptosis Phospho-Specifi EGF Phospho-Specific Arra GPCR Signaling to MAPK ER Nuclear Membrane Receptor Tyrosine Kinase Adaptors Factor VIII Related Anti Factor VIII Related Anti Factor VIII Related Anti Macrophage Colony Stimula Macrophage Colony Stimula Parathyroid Hormone Relat Parathyroid Hormone Relat
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