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#36285625 
2022/10/26
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Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease.
Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by loss of function mutations in 1 of 3 genes, including ), , and ). CCMs affect ≈1 out of 200 children and adults, and no pharmacologic therapy is available. CCM lesion count, size, and aggressiveness vary widely among patients of similar ages with the same mutation or even within members of the same family. However, what determines the transition from quiescent lesions into mature and active (aggressive) CCM lesions is unknown.Catherine Chinhchu Lai, Bliss Nelsen, Eduardo Frias-Anaya, Helios Gallego-Gutierrez, Marco Orecchioni, Victoria Herrera, Elan Ortiz, Hao Sun, Omar A Mesarwi, Klaus Ley, Brendan Gongol, Miguel Alejandro Lopez-Ramirez
