Search results for: Genomic DNA - Asthma Lung, from a single donor
#33008450 
2020/10/02
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TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma.
Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease, but it has been difficult to understand their roles due to the lack of distinct molecular markers. We studied genome-wide DNA methylation and gene expression in airway and parenchymal lung fibroblasts from healthy and asthmatic donors, to identify a robust cell marker and to determine if these cells are molecularly distinct in asthma.Rachel L Clifford, Chen Xi Yang, Nick Fishbane, Jamie Patel, Julia L MacIsaac, Lisa M McEwen, Sean T May, Marcos Castellanos-Uribe, Parameswaran Nair, Ma'en Obeidat, Michael S Kobor, Alan J Knox, Tillie-Louise Hackett
2975 related Products with: TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma.
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#29329322 2018/01/12
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Methylene-tetrahydrofolate reductase contributes to allergic airway disease.
Environmental exposures strongly influence the development and progression of asthma. We have previously demonstrated that mice exposed to a diet enriched with methyl donors during vulnerable periods of fetal development can enhance the heritable risk of allergic airway disease through epigenetic changes. There is conflicting evidence on the role of folate (one of the primary methyl donors) in modifying allergic airway disease.Kenneth R Eyring, Brent S Pedersen, Kenneth N Maclean, Sally P Stabler, Ivana V Yang, David A Schwartz
1839 related Products with: Methylene-tetrahydrofolate reductase contributes to allergic airway disease.
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#27513438 2016/09/21
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Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection.
Rhinovirus (RV) infection in asthma induces varying degrees of airway inflammation (e.g. neutrophils), but the underlying mechanisms remain unclear.C Huang, D Jiang, D Francisco, R Berman, Q Wu, J G Ledford, C M Moore, Y Ito, C Stevenson, D Munson, L Li, M Kraft, H W Chu