ELISA Glucose transporter type 1, erythrocyte_brain,Glut1,GLUT-1,Glut-1,Rat,Rattus norvegicus,Slc2a1,Solute carrier family 2, facilitated glucose transporter member 1 productsSearch results for: ELISA Glucose transporter type 1, erythrocyte_brain,Glut1,GLUT-1,Glut-1,Rat,Rattus norvegicus,Slc2a1,Solute carrier family 2, facilitated glucose transporter member 1
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Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma.
We have carried out SEREX (serological identification of antigens by recombinant cDNA expression cloning), and identified SLC2A1 (solute carrier family 2/facilitated glucose transporter, member 1) as an antigen recognized by serum IgG antibodies in patients with esophageal squamous cell carcinoma (SCC). The levels of serum anti-SLC2A1 antibodies (s-SLC2A1-Abs), examined by enzyme-linked immunosorbent assay using bacterially expressed glutathione-S-transferase-SLC2A1 fusion protein, were significantly higher in patients with esophageal SCC than in healthy donors. When using a cut-off level as the mean + 2x standard deviations of healthy donors, a total of 12 (21%) out of 57 SCC patients were revealed as positive for s-SLC2A1-Abs. The presence of s-SLC2A1-Abs was not associated with either clinicopathological factors or survival. Because s-SLC2A1-Abs were not associated with the positivity of other conventional serum markers, a combination assay of s-SLC2A1-Abs with these conventional serum markers may be useful for the diagnosis and monitoring of esophageal SCC.Mari Kuboshima, Hideaki Shimada, Tian-Ling Liu, Kazue Nakashima, Fumio Nomura, Masaki Takiguchi, Takaki Hiwasa, Takenori Ochiai
