Search results for: ELISA COLEC1,Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding protein C,MBL,MBL2,MBP1,MBP-C
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MicroRNA-181b-5p attenuates early postoperative cognitive dysfunction by suppressing hippocampal neuroinflammation in mice.Postoperative cognitive dysfunction (POCD) is a common complication after surgery and its occurrence is associated with increased morbidity and mortality. However, the pathophysiology of this complication remains largely unknown. Efforts to identify causes of POCD have focused on the hippocampal neuroinflammation. Recently, accumulated evidence indicates that NeurimmiRs, a subset of microRNAs (miRNAs), which modulate both neuronal and immune processes, play an important role in neuroinflammation. However, the impact of NeurimmiRs on POCD has not been investigated. We hypothesized that NeurimmiRs is involved in surgery-induced cognitive impairment in adult mice via mediating hippocampal neuroinflammation.
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The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca/PKC/p38/NF-κB signaling pathway in macrophages.Poria cocos polysaccharide (PCP), extracted from Poria cocos sclerotium, has many biological activities. The present study explored the immunomodulatory effect and the underlying molecular mechanism of PCP in RAW 264.7 macrophages. Griess reaction, ELISA assays and confocal laser scanning microscopy revealed that the production of nitric oxide (NO), TNF-α, IL-1β, IL-6 and intracellular calcium level were increased by PCP. However, this effect on cytokines was suppressed with a Ca channel blocker or a p38 inhibitor, which indicates that Ca and p38 are crucial to the immunomodulatory effect of PCP. We further demonstrated that PCP-treated cells also exhibited increased the activity of PKC, mRNA and protein expression levels of p38 and NF-κB, which is also reduced with a Ca channel blocker. Taken together, the Ca/PKC/p38/NF-κB signaling pathway may involve in the immunomodulatory effects of PCP.
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Epithelial Cell Death Markers in Bronchoalveolar Lavage Correlate with Chronic Lung Allograft Dysfunction Subtypes and Survival in Lung Transplant Recipients - a single-center retrospective cohort study.Chronic lung allograft dysfunction (CLAD) remains the leading cause of late death after lung transplantation. Epithelial injury is thought to be a key event in the pathogenesis of CLAD. M30 and M65 are fragments of cytokeratin-18 released specifically during epithelial cell apoptosis and total cell death, respectively. We investigated whether M30 and M65 levels in bronchoalveolar lavage (BAL) correlate with CLAD subtypes: restrictive allograft syndrome (RAS) vs. bronchiolitis obliterans syndrome (BOS).
2301 related Products with: Epithelial Cell Death Markers in Bronchoalveolar Lavage Correlate with Chronic Lung Allograft Dysfunction Subtypes and Survival in Lung Transplant Recipients - a single-center retrospective cohort study.Lung squamous cell carcin Small cell lung carcinoma Non small cell lung carci Lung non small cell cance Non small cell lung carci Lung small cell carcinoma High density non small ce Middle advanced stage lun Multiple lung carcinoma ( Lung large cell carcinoma Non-small cell lung cance Lung disease spectrum tis
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Quantitative proteomic analysis of venom from Southern India common krait (Bungarus caeruleus) and identification of poorly immunogenic toxins by immune-profiling against commercial antivenom.To study the venom proteome composition of Southern India (SI) Common Krait (Bungarus caeruleus) and immunological cross-reactivity between venom against commercial antivenom.
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MicroRNA-126 affects cell apoptosis, proliferation, cell cycle and modulates VEGF/TGF-β levels in pulmonary artery endothelial cells.In the clinic, therapeutic options for pulmonary arterial hypertension are limited; therefore, investigating the therapeutic strategies and novel therapies is critical for pulmonary arterial hypertension (PAH) treatment. This study aimed to evaluate the role of miRNA-126 (miR-126) and its associated signaling pathways and specific mechanisms for the pathogenesis of PAH.
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Abatacept alleviates rheumatoid arthritis development by inhibiting migration of fibroblast-like synoviocytes via MAPK pathway.To investigate whether Abatacept could regulate the occurrence and progression of rheumatoid arthritis (RA) by mediating cell migration of fibroblast-like synoviocytes (FLS) via mitogen-activated protein kinase (MAPK) pathway.
1688 related Products with: Abatacept alleviates rheumatoid arthritis development by inhibiting migration of fibroblast-like synoviocytes via MAPK pathway.GPCR Signaling to MAPK ER MAPK Phospho-Specific Arr Primary Antibody Dropper MAPKAPK2 MAPKAPK2(dn) MAPKAPK2(ca) MAPK7 MAPKAPK5 MAPKKKK5 Recombinant Viral Antige Recombinant Viral antige Recombinant Viral antige
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Lycopene protects myocardial ischemia injury through anti-apoptosis and anti-oxidative stress.The aim of this research was to explore the protective effect of lycopene (Lyc) on myocardial ischemia injury through anti-apoptosis and anti-oxidative stress.
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MiR-181b regulates atherosclerotic inflammation and vascular endothelial function through Notch1 signaling pathway.To explore the influences of micro ribonucleic acid (miR)-181b on the inflammation and vascular endothelial function in atherosclerosis (AS), and its specific molecular regulatory mechanism.
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Correlation analysis of TLR9 and IL-23 expression in patients with lupus nephritis.The aim of this study was to investigate the expression levels of toll-like receptor 9 (TLR9) and interleukin-23 (IL-23) in renal tissue and serum of patients with lupus nephritis (LN), and to explore their clinical correlation.
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[Preparation of multi-epitope recombinant diagnostic antigen of Mycobacterium tuberculosis].Multi-epitope recombinant diagnostic antigen (designated 'B102') of Mycobacterium tuberculosis (Mtb) was prepared and evaluated as a serological diagnostic antigen. With TRX at the N-terminal and His tag at the C-terminal, the multi-epitope Mtb recombinant diagnostic antigen including 11 predicted B-cell epitopes from 6 Mtb antigens (PstS1, ESAT6, CFP10, Ag85B, Ag85A and PPE54) was expressed in Escherichia coli BL21 (DE3) and purified by Ni²⁺-Chelating affinity and DEAE anion exchange chromatography. Based on the antigenicity of B102 confirmed in Western blotting analysis, we constructed and evaluated a double-antigen sandwich ELISA for diagnosis of Mtb infection. The protein B102 exists in the form of inclusion bodies, accounting for 31.25% of the total proteins of the bacteria. After purification and renaturation, protein B102 exists in soluble form with the concentration 3.124 mg/mL and the homogeneity 96.71%. WB analysis demonstrated that protein B102 could react with antibodies in Mtb positive serum. Using the novel antigen in ELISA, we tested 60 Mtb-related positive and negative serum; The results showed the sensitivity, specificity, positive and negative predictive values and coincidence rate of the detection method is 90.00%, 93.33%, 93.10%, 90.32% and 91.67%, respectively. The McNemer analysis suggested there was no statistical difference between the 'Gold standard' and the novel ELISA with kappa 0.833, which suggested the excellent consistency. By prokaryotic expression and chromatography purification, the multi-epitope recombinant antigen B102 was obtained with excellent antigenicity, which could be applied for Mtb-related serological detection.
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