Search results for: Cat IgE
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Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation).The immunological profiles of human specific IgE (sIgE) and specific IgG4 (sIgG4) vary by genetic predisposition, living conditions in different geographical locations and patient's age. The aim of our study was to analyze sIgE and sIgG4 patterns and their age-dependent changes in patients from the Moscow region. For identifying sIgE and sIgG4 profiles the blood samples from 513 patients aged 6 months to 17 years who were showing symptoms of allergic diseases were analyzed using microarrays containing 31 allergens. The highest sIgE prevalence was observed for birch pollen (32%) among pollen allergens, cat dander (24%) among indoor allergens, and egg whites (21%) among food allergens. The most common sIgG4 response was developed toward egg whites (80% of patients). Age-related elevation was identified for patients with increased sIgE to pollen allergens and indoor allergens (cat or dog dander and house dust mites). For each allergen, the proportion of cases with significant levels of sIgG4 appeared to increase with patients' age. The data on allergen-specific sIgE and sIgG4 prevalence show both general trends and some local special aspects that are indicative for the Moscow region. This information should be useful in terms of epidemiology of allergic diseases.
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Role of nasal challenge and local eosinophilia in indirect exposure to cat in allergic rhinitis patients.Sensitization to cat allergens is common worldwide. Currently, there is a trend towards costly and often unavailable diagnostic analysis.The aim is to assess the reliability of skin prick test (SPT) and serum specific IgE (ssIgE) to cat sensitization, by performing nasal challenge test (NCT) in a community with low cat ownership but common presence of stray cats.Forty-one pa-tients with perennial allergic rhinitis (AR) who were mono or polysensitized (including cat) were included. We had 31 cat non-owners and 10 present cat owners. SPT (> 5 mm / diameter), ssIgE (≥ 0.70 IU/ml), nasal smear for eosinophil (Eo) and NCT were compared between groups. Outcomes included nasal challenge score, nasal Eo positivity, peak inspiratory and expiratory flow (PIF and PEF) 2 and 8 hours after the NCT, and were compared to baseline.Baseline SPT wheal size and ssIgE level were similar in both groups. NCT positivity was more frequent in cat owners. The strongest nasal reaction was on the top concentration in both groups. Nasal Eo positivity in cat owners was higher before and 2 hours after NCT, but similar to non-owners at last measurement. NCT positive cat non-owners had bigger SPT wheal size than NCT negative non-owners, but smaller than NCT positive cat owners. In contrast to PEF, a significant fall in PIF was noticed in both groups. Mono and polysensitised patients showed similar NCT positivity.Stray cats may pose a relevant risk of developing perennial AR. Regardless of cat ownership status, SPT and ssIgE should be the first diagnostic tool. Nasal Eo and NCT seem to be good diagnostic tools in cat non-owners if diagnosis is elusive.
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The Effect of Allium cepa Extract on Lung Oxidant, Antioxidant and Immunological Biomarkers in Ovalbumin-Sensitized Rats.To evaluate the effects of Allium cepa (A. cepa) on levels of oxidants, antioxidants and immunological markers in the broncho-alveolar lavage fluids in sensitized rats.
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Modified Allergens for Immunotherapy.During the past few decades, modified allergens have been developed for use in allergen-specific immunotherapy (AIT) with the aim to improve efficacy and reduce adverse effects. This review aims to provide an overview of the different types of modified allergens, their mechanism of action and their potential for improving AIT.
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Evolution of IgE responses to multiple allergen components throughout childhood.There is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins (components) from multiple sources.
2065 related Products with: Evolution of IgE responses to multiple allergen components throughout childhood.High density multiple org Topoisomerase II; Clone Topoisomerase II; Clone Topoisomerase II; Clone Toludine Blue Solution Toludine Blue Solution Toludine Blue Solution Toxoplasma gondii MIC 3 r Toxoplasma gondii P24 (GR Toxoplasma gondii P29 (GR Toxoplasma gondii P30 (SA Allergens, Phospholipase
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Accuracy of serum-specific IgE test with microfluidic array enzyme-linked immunosorbent assay for diagnosing inhalant allergen sensitization in asthma and/or rhinitis allergy patients in Jakarta, Indonesia.Asthma and allergic rhinitis are a global health burden. Inhalant allergens worsen the symptoms and clinical manifestations of asthma and allergic rhinitis. Skin prick test is the gold standard for diagnosing allergen sensitization but is associated with some limitations. In contrast,serum-specific immunoglobulin E (SSIgE) test is convenient and is not associated with an anaphylactic risk.
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An unexpected protective role of low-affinity allergen-specific IgG through the inhibitory receptor FcγRIIb.Induction of allergen-specific IgG antibodies is a critical parameter for successful allergen-specific immunotherapy. IgG antibodies can inhibit IgE-mediated mast cell activation through direct allergen neutralization or through the inhibitory receptor FcγRIIb. The affinity of IgE antibodies to the allergen has been shown to be critical for cellular activation.
1359 related Products with: An unexpected protective role of low-affinity allergen-specific IgG through the inhibitory receptor FcγRIIb.MOUSE ANTI BOVINE ROTAVIR EIA for Quantitative Dete EIA for Quantitative Dete House Dust Mite Allergen Anti-Rabbit IgG, H&L Chai IGF-1R Signaling Phospho- Insulin Receptor Phospho- Nuclear Membrane Receptor T-Cell Receptor Signaling RABBIT ANTI GSK3 BETA (pS Rabbit Anti-Leptin recept Rabbit Anti-Leptin recept
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Development and characterization of an allergoid of cat dander for immunotherapy.Allergy to cats is a frequent cause of sensitization to indoor allergens and currently there are few alternatives to specific immunotherapy with cat native extracts. The objective is to develop and characterize a new allergoid to increase the tools available for use in clinical practice.
1529 related Products with: Development and characterization of an allergoid of cat dander for immunotherapy.MOUSE ANTI BOVINE ROTAVIR â Catenin (Phospho Thr41 Androgen Receptor (Phosph Androgen Receptor (Phosph â Catenin (Phospho Ser33 â Catenin (Phospho Ser37 α-catenin (Phospho-Ser64 β-catenin (phospho-Tyr33 Rabbit Anti-Human Androge Rabbit Anti-Human Androge MOUSE ANTI BORRELIA BURGD â Catenin (Ab 41 45) Ant
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Consensus document on dog and cat allergy.The prevalence of sensitization to dogs and cats varies by country, exposure time and predisposition to atopy. It is estimated that 26% of European adults coming to the clinic for suspected allergy to inhalant allergens are sensitized to cats and 27% to dogs. This document is intended to be a useful tool for clinicians involved in the management of people with dog or cat allergy. It was prepared from a consensus process based on the RAND/UCLA method. Following a literature review, it proposes various recommendations concerning the diagnosis and treatment of these patients, grounded in evidence and clinical experience. The diagnosis of dog and cat allergy is based on a medical history and physical examination that are consistent with each other and is confirmed with positive results on specific IgE skin tests. Sometimes, especially in polysensitized patients, molecular diagnosis is strongly recommended. Although the most advisable measure would be to avoid the animal, this is often impossible and associated with a major emotional impact. Furthermore, indirect exposure to allergens occurs in environments in which animals are not present. Immunotherapy is emerging as a potential solution to this problem, although further supporting studies are needed.
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Occupational allergy to Spagulax.We report the case of a 36-year-old male pharmaceutical laboratory worker. On handling Spagulaxsachets whose content is a laxative called Plantago ovata, he immediately presented rhinoconjunctivitis.Specific allergy study included SDS-PAGE with Western Blot and specific nasal challenge to Plantago ovata extract.Prick by prick for Spagulaxwas negative. Total IgE: 126.5 U/mL. Western Blot recognized two proteins of 15 and 20 kDa in the extract of Plantago ovata and three proteins of 15, 18 and 50 kDa in the extract of Plantago lanceolata.We present a case of occupational allergy due to inhalation of and/or contact with Plantago ovata seeds.
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