Search results for: CD200 _ OX_2 ELISA kit , Human ELISA kit
#34439393 
2021/08/23
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CD200 Baseline Serum Levels Predict Prognosis of Chronic Lymphocytic Leukemia.
Membrane-bound CD200 is overexpressed in chronic lymphocytic leukemia (CLL), and there is some evidence that its soluble ectodomain (sCD200) could also be involved in the pathophysiology and the disease. However, very little is known about sCD200's prognostic significance. sCD200 was tested at diagnosis in 272 patients with CLL and in 78 age- and sex-matched healthy subjects using a specific human CD200 (OX-2 membrane glycoprotein) ELISA kit. A significantly higher concentration of sCD200 was found in CLL patients compared to controls. In our cohort, sCD200 was significantly higher in patients who were older than 66 years, with Binet stage C, unmutated IgVH and unfavorable (del11q or del17p) FISH. Time-to-first treatment and overall survival were significantly shorter in patients with higher sCD200 concentration, using as a cut-off 1281 pg/mL, the median value for sCD200 concentration in the whole CLL cohort. However, the prognostic impact of sCD200 was not confirmed in multivariate analysis. Baseline sCD200 values appeared to have an impact on the response to chemotherapy or chemo-immunotherapy, but not to targeted agents. Collectively, our data show that sCD200 serum levels correlate with more aggressive clinical and biological features and are able to predict a worse prognosis. This work supports the relevant role of CD200 not only as a diagnostic tool but also as a prognostic indicator and a potential therapeutic target in CLL.Giovanni D'Arena, Candida Vitale, Marta Coscia, Daniela Lamorte, Giuseppe Pietrantuono, Francesca Perutelli, Fiorella D'Auria, Teodora Statuto, Luciana Valvano, Annamaria Tomasso, Valentina Griggio, Rebecca Jones, Giovanna Mansueto, Oreste Villani, Simona D'Agostino, Vito Viglioglia, Vincenzo De Feo, Fabrizio Calapai, Carmen Mannucci, Alessandro Sgambato, Dimitar G Efremov, Luca Laurenti
1843 related Products with: CD200 Baseline Serum Levels Predict Prognosis of Chronic Lymphocytic Leukemia.
One 96-Well Strip Micropl1ml100 ml96T1000ml1 ml50 Each50ul 6 ml Ready-to-use 100mg
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#24964809 2014/06/26
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Evaluation of soluble CD200 levels in type 2 diabetic foot and nephropathic patients: association with disease activity.
CD200 (OX-2) is a novel immune-effective molecule, existing in a cell membrane-bound form, as well as in a soluble form in serum (s OX-2), which acts to regulate inflammatory and acquired immune responses.Hasan Onur Arik, Arzu Didem Yalcin, Betul Celik, Derya Seyman, Gulsum Tetik, Bensu Gursoy, Sukran Kose, Saadet Gumuslu