Search results for: Boc_Pro
#8540900 // To Up
[Synthesis of stearoyl derivatives of proline-containing hydrophobic peptides].
Hydrophobic stearoyl derivatives of proline-containing di- and tripeptides and their deuterated analogs were synthesized. It was shown by NMR spectroscopy that cis-trans-equilibrium around an X-Pro peptide bond is displaced towards trans-conformers for compounds containing a Ste-Pro fragment as opposed to the compounds containing Boc-Pro or Gly-Pro fragments.F Kh Iskhakova, O V Esipova, E N Zvonkova
1268 related Products with: [Synthesis of stearoyl derivatives of proline-containing hydrophobic peptides].
5 G10 g1 mg100 mg100 mg 1 G1 g25 g96T 1 G 25 G1 gRelated Pathways
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#7007264 // To Up
Preferred conformation of the tert-butoxycarbonyl-amino group in peptides.
Structural parameters, derived from X-ray crystallographic data, have been compiled for amino acid and linear peptide derivatives which contain the N-terminal tert-butoxycarbonyl (Boc) group or its next higher homolog, the tert-amyloxycarbonyl group. The comparison of the geometry of the urethane group in Boc-derivatives with that of the peptide group shows small differences in bond angles about the trigonal carbon, because of altered interactions when a C alpha H group of a peptide unti is replaced by an ester oxygen. In contrast to the strong preference of the peptide bond for the trans form (except when it precedes proline), the urethane amide bond adopts both the cis and trans conformations in crystals. The cis urethane conformation is preferred in crystals of compounds with a tertiary nitrogen (such as Boc-Pro) or in structures stabilized by strong intermolecular interactions. Conformational energy computations on Boc-amino acid N'-methylamides indicate that the trans and cis conformations of the urethane amide bone have nearly equal energies (even for amino acids other than proline), in contrast to the peptide bond, for which the trans conformation has a much lower energy. The computed increase of the cis content in Boc-amino acid derivatives (as compared with the corresponding N-acetyl derivatives) is consistent with the observed distributions of conformations in crystal structures and with n.m.r. studies in solution. Usually, the substitution of a Boc for an N-acetyl end group does not alter the conformational preferences (as indicated by phi, psi values and relative energies) of the amino acid residue which follows the end group when the amide bond is trans. Particular conformations, however, can be stabilized by strong attractive interactions between some side chains (e.g. that of phenylalanine) the the bulky Boc end group.E Benedetti, C Pedone, C Toniolo, G Némethy, M S Pottle, H A Scheraga
2614 related Products with: Preferred conformation of the tert-butoxycarbonyl-amino group in peptides.
2.5 g5 mg100 mg250 mg10 mg10 mg50 mg5 mg5 mg0.5 mg250 mg10reactionsRelated Pathways
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