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An electrophilic reagent for the synthesis of OCHFMe-containing molecules.

Herein the synthesis of a novel and bench stable electrophilic reagent to construct the OCFHMe motif from O-nucleophiles has been described. This sulfonium salt, readily obtained in 5 steps, reacted with various phenols and alcohols. The resulting products, including complex molecules, were obtained in good yields. This reagent was also used for the functionalization of thiol derivatives.

1210 related Products with: An electrophilic reagent for the synthesis of OCHFMe-containing molecules.

MOUSE ANTI BOVINE ROTAVIR Annexin V FITC Reagent Annexin V FITC Reagent100 Annexin V FITC Reagent Annexin V FITC Reagent200 Annexin V Cy3 Reagent Annexin V Cy3 Reagent1000 Annexin V Cy3 Reagent Annexin V Cy3 Reagent200 Annexin V-Biotin Reagent Annexin V Biotin Reagent Annexin V Biotin Reagent1

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1,3-Iodo-amination of 2-methyl indoles via C-Cdual functionalization with iodine reagent.

A 1,3-iodo-amination with iodine reagent that involved the C-Cdual functionalization of 2-methyl indoles was developed to provide 2-aminomethyl-3-iodo-indole derivatives. The iodo-amination proceeded via a 1,4-transfer of an imide group through the formation of an indolyl(phenyl)iodonium imide using PhI(OAc), followed by an iodination using DIH or a double iodination of indole using excess DIH.

1212 related Products with: 1,3-Iodo-amination of 2-methyl indoles via C-Cdual functionalization with iodine reagent.

N (di Methyl amino naphth N (di Methyl amino naphth 7 Amino 4 methylcoumarin, 4 Iodo 2 methylaniline CA 3 Iodo 4 methylbenzoic ac 2 Fluoro 4 iodo 5 picolin 3 Iodo 4 methylaniline CA Reagent grade heat shock Reagent grade heat shock Reagent grade heat shock Bluing Reagent Bluing Reagent

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Sorption kinetics, isotherms, and mechanism of aniline aerofloat to agricultural soils with various physicochemical properties.

Aniline aerofloat (AAF), a high-toxic organic flotation reagent, is widely used in mineral processing industry. However, little information on its environmental fate is available. AAF sorption to four types of agricultural soils at low concentrations (1-10 mg/L) was investigated using batch experiments. AAF sorption kinetics involved both boundary layer diffusion and intraparticle diffusion, following pseudo-second-order kinetics with equilibrium time within 120 min. Both Langmuir and Freundlich models fitted well the AAF sorption with the former better. Sorption of AAF to soils was a spontaneous and favorable physical sorption that was controlled by ion bridge effect and hydrophobic interaction that was related to van der Waals force and π-π coordination based on FTIR analyses. AAF sorption was remarkably affected by soil constituents, positively correlating with the contents of organic matter and clay. The relatively higher logKvalues (3.53-4.66) of AAF at environmental concentrations (1-5 mg/L) imply that soils are serving as a sink of AAF from beneficiation wastewater, posing great potential risks to environment and human health.

2083 related Products with: Sorption kinetics, isotherms, and mechanism of aniline aerofloat to agricultural soils with various physicochemical properties.

AZD-3514 Mechanisms: Andr Topoisomerase II; Clone Topoisomerase II; Clone Topoisomerase II; Clone Aniline Blue - Orange G Aniline Blue - Orange G Aniline Blue Solution Aniline Blue Solution Aniline Blue Solution Toludine Blue Solution Toludine Blue Solution Toludine Blue Solution

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Behavioral toxicity of sodium cyanide following oral ingestion in rats: Dose-dependent onset, severity, survival, and recovery.

Sodium cyanide (NaCN) is a commonly and widely used industrial and laboratory chemical reagent that is highly toxic. Its availability and rapid harmful/lethal effects combine to make cyanide a potential foodborne/waterborne intentional-poisoning hazard. Thus, laboratory studies are needed to understand the dose-dependent progression of toxicity/lethality following ingestion of cyanide-poisoned foods/liquids. We developed an oral-dosing method in which a standard pipette was used to dispense a sodium cyanide solution into the cheek, and the rat then swallowed the solution. Following poisoning (4-128 mg/kg), overt toxic signs were recorded and survival was evaluated periodically up to 30 hours thereafter. Toxic signs for NaCN doses higher than 16 mg/kg progressed quickly from head burial and mastication, to lethargy, convulsions, gasping/respiratory distress, and death. In a follow-on study, trained operant-behavioral performance was assessed immediately following cyanide exposure (4-64 mg/kg) continuously for 5 h and again the following day. Onset of behavioral intoxication (i.e., behavioral suppression) occurred more rapidly and lasted longer as the NaCN dose increased. This oral-consumption method with concomitant operantbehavioral assessment allowed for accurate dosing and quantification of intoxication onset, severity, and recovery, and will also be valuable in characterizing similar outcomes following varying medical countermeasure drugs and doses.

1199 related Products with: Behavioral toxicity of sodium cyanide following oral ingestion in rats: Dose-dependent onset, severity, survival, and recovery.

GST Inhibitor 1 (Cibacron N-Acetyl-2-O-(5-bromo-1H- 1-Benzyl-3-hydroxy-1H-ind Mouse Protein Z-Dependent Methyl purple sodium salt 5 Bromo 4 chloro 3 indoly Oral cavity squamous cell Oral squamous cell cancer Phosphatase Inhibitor (So Oral cavity tumor test ti Oral cavity cancer test t Anti-DAT(Sodium-dependent

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HPTLC determination of diosgenin in fenugreek seeds.

A new HPTLC-densitometric method for diosgenin determination in fenugreek seeds was established after optimization of the conditions for efficient saponin extraction and acid hydrolysis. Several procedures were tested, the best of which was a three-step Soxhlet extraction, followed by hydrolysis of the obtained methanolic extract with 2 mol L-1 H2SO4. Best diosgenin separation from other hydrolysis products was obtained on HPTLC Si60F254 plates u sing a mixture of n-heptane/ethyl acetate (7:3, V/V) and modified anisaldehyde as a spraying reagent. The method was preliminarily validated and the determined amounts of diosgenin in fenugreek seeds of Polish and African origin were found to be similar and ranged from 0.12-0.18 %.

2215 related Products with: HPTLC determination of diosgenin in fenugreek seeds.

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Fenton treatment of bio-treated fermentation-based pharmaceutical wastewater: removal and conversion of organic pollutants as well as estimation of operational costs.

The Fenton process is used as a tertiary treatment to remove organic pollutants from the effluent of bio-treated pharmaceutical wastewater (EBPW). The optimal and most appropriate Fenton conditions were determined by an orthogonal array test and single-factor experiments. The removal of chemical oxygen demand (COD) was influenced by the following factors in a descending order: HO/Fe(II) molar ratio > HOdosage > reaction time. Under the most appropriate Fenton conditions (HO/Fe(II) molar ratio of 1:1, HOdosage of 120 mg Land reaction time of 10 min), the COD and dissolved organic carbon (DOC) were removed with efficiencies of 62 and 53%, respectively, which met the national discharge standard (GB 21903-2008) for the Lake Tai Basin, China. However, the Fenton treatment was inadequate for removal of N compounds, and the removal of organic nitrogen led to an increment in N-NHfrom 3.28 to 19.71 mg L. Proteins and polysaccharides were completely removed, and humic acids (HAs) were partly removed with an efficiency of 55%. Three-dimensional excitation/emission matrix spectra (3DEEMs) indicated complete removal of fulvic acid-like substances and 90% reduction in the florescence intensity of humic acid-like substances. Organic pollutants with molecular weights (MW) > 10 kDa were completely removed, MW 5-10 kDa were degraded into smaller MW ones, and some low molecular weight acids (MW 0.1-1 kDa) were mineralized during the Fenton process. Some species, including pharmaceutical intermediates and solvents were detected by gas chromatography-mass spectrometry (GC-MS). The operational costs of the Fenton's treatment were estimated to be 0.58 yuan RMB/mEBPW based on reagent usage and iron sludge treatment and disposal.

1800 related Products with: Fenton treatment of bio-treated fermentation-based pharmaceutical wastewater: removal and conversion of organic pollutants as well as estimation of operational costs.

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Monitoring the Integrity of the Blood-Testis Barrier (BTB): An In Vivo Assay.

The blood-testis barrier is a unique ultrastructure in the mammalian testis, located near the basement membrane of the seminiferous tubule that segregates the seminiferous epithelium into the basal and the adluminal (apical) compartment. Besides restricting paracellular and transcellular passage of biomolecules (e.g., paracrine factors, hormones), water, electrolytes, and other substances including toxicants and/or drugs to enter the adluminal compartment of the epithelium, the BTB is an important ultrastructure that supports spermatogenesis. As such, a sensitive and reliable assay to monitor its integrity in vivo is helpful for studying testis biology. This assay is based on the ability of an intact BTB to exclude the diffusion of a small molecule such as sulfo-NHS-LC-biotin (CHNNaOS, Mr. 556.59, a water-soluble and membrane-impermeable biotinylation reagent) from the basal to the apical compartment of the seminiferous epithelium. Herein, we summarize the detailed procedures on performing the assay and to obtain semiquantitative data to assess the extent of BTB damage when compared to positive controls, such as treatment of rats with cadmium chloride (CdCl) which is known to compromise the BTB integrity.

1330 related Products with: Monitoring the Integrity of the Blood-Testis Barrier (BTB): An In Vivo Assay.

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Solubilization of polycyclic aromatic hydrocarbons (PAHs) with phenol in coking wastewater treatment system: Interaction and engineering significance.

Polycyclic aromatic hydrocarbons (PAHs) are accumulated in the sludge collected from the coking wastewater treatment. Phenol with its efficient degradation observed in biological treatment promotes the solubility of PAHs in aqueous phase. The interaction mechanism of phenol and PAHs in aqueous and sludge phases was systematically studied in two full-scale engineering projects composed of anaerobic-oxic-oxic (A-O-O) and anaerobic-oxic-hydrolytic-oxic (A-O-H-O) sequences. The results showed that reasonable use of phenol facilitates solubilization of PAHs alleviating their emission problems. The ΔPAHs/Δphenol mass ratio in the sludge phase of A-O-H-Osystem (146.3) exceeded that in A-O-Oone (63.80), exhibiting a good solubilization effect on PAHs with their more efficient degradation in the former. The full-scale observations were verified in laboratory solubilization experiments using phenanthrene (Phen), pyrene (Pyr) and benzo[a]pyrene (Bap) as the models of 3-, 4- and 5-ring PAHs, respectively. The binding energies of [phenolPAHs] complexes were calculated using computational density functional theory showing consistency with the experimentally observed phenol-facilitated solubilization efficiencies in the row of Phen>Pyr>Bap. The results showed the fate and distribution of PAHs in coking wastewater treatment affected by the presence of phenol serving as a cost effective reagent for enhanced solubilization of PAHs from the coking wastewater sludge.

2143 related Products with: Solubilization of polycyclic aromatic hydrocarbons (PAHs) with phenol in coking wastewater treatment system: Interaction and engineering significance.

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An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: Irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.

We previously reported that KW-2449, (E)-1-{4-[2-(1H-Indazol-3-yl)vinyl]benzoyl}piperazine, a novel multikinase inhibitor developed for the treatment of leukemia patients, was oxidized to an iminium ion intermediate by monoamine oxidase B (MAO-B) and then converted to its oxo-piperazine form (M1) by aldehyde oxidase (AO). However, we found that the significant decrease in the pharmacologically active metabolite M1 following repeated administration of KW-2449 in primates might hamper the effectiveness of the drug. We investigated the mechanism underlying this phenomenon and found that the AO activity was inhibited in a time-dependent manner in vitro under the co-incubation of KW-2449 and MAO-B, while neither KW-2449 nor M1 strongly inhibited MAO-B or AO activity. These results clearly suggest that MAO-B catalyzed iminium ion metabolite inhibited AO, prompting us to investigate whether or not the iminium ion metabolite covalently binds to endogenous proteins, as has been reported with other reactive metabolites as a cause for idiosyncratic toxicity. We confirmed the association of the radioactivity derived fromC-KW-2449 with endogenous proteins both in vivo and in vitro and verified that this covalent binding was inhibited by the addition of sodium cyanide, an iminium ion-trapping reagent, and pargyline, a MAO-B inhibitor. These findings strongly suggest that the iminium ion metabolite of KW-2449 is highly reactive in inhibiting AO irreversibly and binding to endogenous macromolecules covalently.

1074 related Products with: An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: Irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.

FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu Proteins and Antibodies H anti-Diazepam Binding Inh anti-Diazepam Binding Inh Multiple organ tumor tiss TCP-1 theta antibody Sour Protease Inhibitor 15 ant

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Optimizing NBE PK/PD assays using the Gyrolab Affinity Software; conveniently within the bioanalyst's existing workflow.

The fully automated microfluidics-based Gyrolab is a popular instrument for the bioanalysis of protein therapeutics; requiring minimal sample and reagent volumes. Gyros offers affinity software for determining binding affinity in solution using a high-throughput method and miniaturized reactions.

2826 related Products with: Optimizing NBE PK/PD assays using the Gyrolab Affinity Software; conveniently within the bioanalyst's existing workflow.

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