Gentaur Pub

#34082400   2021/05/31 To Up

Multiple strategies with the synergistic approach for addressing colorectal cancer.

Cancer treatment is improving widely over time, but finding a proper defender to beat them seems like a distant dream. The quest for identification and discovery of drugs with an effective action is still a vital work. The role of a membrane protein called P-glycoprotein, which functions as garbage chute that efflux the waste, xenobiotics, and toxins out of the cancer cells acts as a major reason behind the therapeutic failure of most chemotherapeutic drugs. In this review, we mainly focused on a multiple strategies by employing 5-Fluorouracil, curcumin, and lipids in Nano formulation for the possible treatment of colorectal cancer and its metastasis. Eventually, multidrug resistance and angiogenesis can be altered and it would be helpful in colorectal cancer targeting.We have depicted the possible way for the depletion of colorectal cancer cells without disturbing the normal cells. The concept of focusing on multiple pathways for marking the colorectal cancer cells could help in activating one among the pathways if the other one fails. The activity of the 5-Fluorouracil can be enhanced with the help of curcumin which acts as a chemosensitizer, chemotherapeutic agent, and even for altering the resistance. As we eat to survive, so do the cancer cells. The cancer cells utilize the energy source to stay alive and survive. Fatty acids can be used as the energy source and this concept can be employed for targeting the colorectal cancer cells and also for altering the resistant part.
Chenmala Karthika, Balaji Hari, Md Habibur Rahman, Rokeya Akter, Agnieszka Najda, Ghadeer M Albadrani, Amany A Sayed, Muhammad Furqan Akhtar, Mohamed M Abdel-Daim

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#2220831   // To Up

Practical aspects of sampling for organic dusts and microorganisms.

Air sampling for organic dusts and microorganisms was carried out in silos when moldy silage was discarded through the discharge chute. Concentrations of respirable dust and airborne viable microorganisms exceeded 20 mg/m3 and 1 x 10(9)/m3, respectively, when dry silage was removed from silos. Much lower concentrations of dust and microorganisms were present when wet silage was discarded. Impinger and filter cassette samplers were equally effective in collecting the hardy spores present in silage dusts.
P R Morey

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25 g250 ml0.1 mg2.5 mg 100ul10 200ug100ug200 mg2000 rxn

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