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Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation.
SB-236057 is a potent skeletal teratogen in rodents and rabbits, producing axial and posterior somite malformations in cultured rat embryos. The compound shares some structural similarity to cyclopamine.Karen A Augustine-Rauch, Qin J Zhang, Jennifer L Leonard, Antony Chadderton, Michael J Welsh, Harshad K Rami, Mervyn Thompson, Laramie Gaster, Patrick J Wier
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